Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE LRRK2 gene G2019S mutation and SNPs [haplotypes] in subtypes of Parkinson's disease. 18752982

2009

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE These findings suggest Lrrk2 G2019S may play an important role in Parkinson's disease on the South American Continent and further studies are now warranted. 17614198

2007

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Our data, while limited by a small sample size, show that in LRKK2 G2019S mutation carriers, phenoconversion to PD can occur late in life. 20721910

2010

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE To investigate how LRRK2 might affect Tau and the pathophysiology of PD, we generated lines of C. elegans expressing human LRRK2 [wild-type (WT) or mutated (G2019S or R1441C)] with and without V337M Tau. 22315971

2012

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE The most prevalent PD associated mutation, LRRK2-G2019S</span> is linked to familial and sporadic cases. 31621607

2019

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE We consider that these genes merit further attention in future studies as potential candidate genes involved in both idiopathic and LRRK2-G2019S-associated forms of PD. 25475535

2015

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE These findings demonstrate an important role for LRRK2 protein in regulation of mitochondrial clearance by the lysosomes, which is hampered in PD with the G2019S mutation. 31261377

2019

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R and rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent. 20186690

2010

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Among Chinese subjects who were non-G2019S carriers, we demonstrated the frequency of the LRRK2 G2019S founder haplotype (T-254-A-G-A-154) in Parkinson's disease and controls to be 33% and 30%. 17083102

2007

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Perhaps even more importantly, a low-penetrance LRRK2 mutation (Gly2019Ser) and polymorphic variants in alpha-synuclein and LRRK2 are emerging as relevant genetic determinants for sporadic PD in several populations. 18267242

2007

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE No clear differences were identified in LRRK2 immunoreactivity between control, IPD and G2019S positive PD cases. 21696411

2011

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Within its limitations, this meta-analysis demonstrated that the G2019S, G2385R, R1628P and A419V variations are risk factors associated with increased PD susceptibility. 22575234

2012

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. 28958936

2017

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease. 17078063

2006

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Reduced integrity of non-motor networks was detected among NMC of the G2019S mutation in the LRRK2 gene prior to identifiable changes in connectivity of the motor network, indicating significant non-motor cerebral changes among populations "at risk" for future development of PD. 30793410

2019

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE The concentration of mitochondrial DNA was measured using a digital droplet polymerase chain reaction technique in a total of 98 CSF samples from a cohort of subjects including: 20 LRRK2(G2019S) mutation carriers with Parkinson's disease, 26 asymptomatic LRRK2(G2019S) mutation carriers, 31 patients with idiopathic Parkinson's disease and 21 first-degree relatives of LRRK2 Parkinson's disease patients without the mutation. 27260835

2016

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is recognized as the most common cause of familial autosomal dominant and also sporadic forms of Parkinson disease (PD). 19172321

2009

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene. 29414418

2018

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Among 192 patients with Parkinson's disease (mean age±SD, 63.9±11.8 years; disease onset, 54.0±12.5 years; family history for Parkinson's disease or tremor, 45%), 8 carried a heterozygous R1441C mutation, whereas only 1 had the G2019S mutation. 21538529

2011

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE G2019S mutation of the leucine-rich repeat kinase 2 gene in a cohort of Egyptian patients with Parkinson's disease. 21699405

2011

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. 25330404

2014

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE The risk of PD for a person who inherits the LRRK2 Gly2019Ser mutation was 28% at age 59 years, 51% at 69 years, and 74% at 79 years. 18539534

2008

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE The PD LRRK2-G2019S associated profile was positively matched with expression changes induced by the Parkinsonian neurotoxin rotenone and opposed by those induced by clioquinol, a compound with demonstrated therapeutic efficacy in multiple PD models. 28096185

2017

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families. 17115391

2007

dbSNP: rs34637584
rs34637584
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.900 GeneticVariation BEFREE Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. 26651604

2015