Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1554931219
rs1554931219
BDNF ; BDNF-AS
CUI: C1849265
Disease: Overgrowth
Overgrowth 		A 0.700 GeneticVariation CLINVAR Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. 11579207

2001
dbSNP: rs1554931219
rs1554931219
BDNF ; BDNF-AS
CUI: C0026827
Disease: Muscle hypotonia
Muscle hypotonia 		A 0.700 GeneticVariation CLINVAR Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. 11579207

2001
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. 11782995

2002
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. 11782995

2002
dbSNP: rs8192466
rs8192466
BDNF ; BDNF-AS
CUI: C1275808
Disease: Congenital central hypoventilation
Congenital central hypoventilation 		0.700 GeneticVariation UNIPROT Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation. 11840487

2002
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.090 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.090 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.070 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.070 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs746682028
rs746682028
BDNF ; BDNF-AS
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.020 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs746682028
rs746682028
BDNF ; BDNF-AS
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.020 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment. 12951204

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment. 12951204

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population. 14642442

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population. 14642442

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.100 GeneticVariation BEFREE This study has examined the association between the BDNF gene Val66Met polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese sample population. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.100 GeneticVariation BEFREE This study has examined the association between the BDNF gene Val66Met polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese sample population. 14673216

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003