|
rs779221554
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs770462360
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs757496714
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs375412266
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs371854396
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs17855787
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs1567176006
|
|
Glioblastoma Multiforme
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs1558650888
|
|
Glioblastoma Multiforme
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs1466858740
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs1402272180
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs1384093596
|
|
Glioblastoma Multiforme
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs7003908
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
A 44% increase in risk for glioblastoma multiforme was found for individuals homozygous for the G allele of the PRKDC rs7003908 variant (odds ratio(GG), 1.44; 95% confidence interval, 1.13-1.84); there was a statistically significant trend (P = 0.009) with increasing number of G alleles.
|
19318434 |
2009 |
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
A clonal IDH1 R132H mutation in the primary, a known GBM driver event, was detectable at only very low frequency in the recurrent tumour.
|
25732040 |
2015 |
|
rs55819519
|
|
Glioblastoma Multiforme
|
|
0.080 |
GeneticVariation
|
BEFREE |
A clonal IDH1 R132H mutation in the primary, a known GBM driver event, was detectable at only very low frequency in the recurrent tumour.
|
25732040 |
2015 |
|
rs2017309
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
A genetic polymorphism of the CHEK2 gene (CHEK2 SNP rs2017309 A/T) was genotyped in a series of glioblastoma patients (n = 213) and population controls (n = 192).
|
17016233 |
2006 |
|
rs8957
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
A missense variant, rs8957 (E[GAG]233D[GAU], SLC2A4RG, 20q13.33), was found being associated with GBM risk, with an odd ratio (OR) of 1.43 (95% confidence interval (CI) = 1.25-1.64, <i>P</i> = 1.72E-07).
|
28979815 |
2017 |
|
rs121913500
|
|
Glioblastoma Multiforme
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 15.3% of enrolled GBMs demonstrated loss of ATRX expression (ATRX-), 10.4% expressed an aberrant IDH1 R132H protein (IDH1+), and 48.4% exhibited p53 overexpression (p53+).
|
27478330 |
2016 |
|
rs55819519
|
|
Glioblastoma Multiforme
|
|
0.080 |
GeneticVariation
|
BEFREE |
A total of 15.3% of enrolled GBMs demonstrated loss of ATRX expression (ATRX-), 10.4% expressed an aberrant IDH1 R132H protein (IDH1+), and 48.4% exhibited p53 overexpression (p53+).
|
27478330 |
2016 |
|
rs74315452
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Activation of caspase-1 and caspase-3 is observed also in neuroblastoma lines expressing other fALS-SOD1s (G37R, G85R, and I113T) cocultured with glioblastoma lines expressing the corresponding mutant enzymes.
|
15208263 |
2004 |
|
rs373584770
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Activation of caspase-1 and caspase-3 is observed also in neuroblastoma lines expressing other fALS-SOD1s (G37R, G85R, and I113T) cocultured with glioblastoma lines expressing the corresponding mutant enzymes.
|
15208263 |
2004 |
|
rs3851634
|
|
Glioblastoma Multiforme
|
T |
0.710 |
GeneticVariation
|
GWASCAT |
After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)).
|
26424050 |
2015 |
|
rs3851634
|
|
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
BEFREE |
After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)).
|
26424050 |
2015 |
|
rs11196067
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)).
|
26424050 |
2015 |
|
rs1801591
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)).
|
26424050 |
2015 |
|
rs648044
|
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10(-9)) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10(-8)), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10(-11)), 12q21.2 (rs12230172, P=7.53 × 10(-11)) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10(-9)).
|
26424050 |
2015 |