Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17366743
rs17366743
Diabetes Mellitus, Non-Insulin-Dependent
0.030 GeneticVariation BEFREE Gly15Gly polymorphism within the human adipocyte-specific apM-1gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes. 11571669

2001

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The two SNPs (45T-->G and 276G-->T) were chosen because of their association with type 2 diabetes in Japanese. 12086965

2002

dbSNP: rs185847354
rs185847354
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Our findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes. 12086969

2002

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects. 15842511

2005

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. 17973869

2007

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Adiponectin gene polymorphism 45T>G is associated with carotid artery plaques in patients with type 2 diabetes mellitus. 18191060

2008

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These data suggest that the adiponectin allele 45T/G and -11377C/G polymorphisms are significantly associated with the therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with T2D. 18429970

2008

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE On the contrary, -11377C/G (rs266729) was associated with type 2 diabetes in the obese group only (OR=2.45, 95%CI: 1.13-5.31, P=0.02), and 59% risk of diabesity could be attributed to that. 19359061

2009

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Thus, our results demonstrated that, adiponectin SNP 45T/G, rather than SNP 276G/T, is more associated with risk of T2DM in obese individuals. 19929719

2009

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. 19631916

2009

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. 19631916

2009

dbSNP: rs16861194
rs16861194
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation BEFREE To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95%CI 1.08-1.55). 19631916

2009

dbSNP: rs182052
rs182052
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE The SNP rs182052 in intron 1 of the adiponectin gene is associated with type 2 diabetes in African Americans. 19056609

2009

dbSNP: rs1063539
rs1063539
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE Among these mutations, the 4545G/C mutation (rs1063539) contributed to the genetic risk of T2D in the non-obese group (OR=2.34, 95%CI: 1.31-4.21, P=0.004), and 57% of the risk is related to this polymorphism. 19359061

2009

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis. 20580771

2010

dbSNP: rs182052
rs182052
Diabetes Mellitus, Non-Insulin-Dependent
0.040 GeneticVariation BEFREE In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026). 19846176

2010

dbSNP: rs141205818
rs141205818
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. 19269196

2010

dbSNP: rs7649121
rs7649121
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026). 19846176

2010

dbSNP: rs747223144
rs747223144
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Whereas each polymorphism studied (T45G, G276T, and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was overrepresented in our diabetic population (9.3% against 3.1% in NGT individuals, P=.0003). 19269196

2010

dbSNP: rs138773406
rs138773406
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. 19269196

2010

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE However, G vs C allele of -11377C>G (rs266729) might be a risk factor for type 2 diabetes. 21638131

2011

dbSNP: rs266729
rs266729
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM. 21219602

2011

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2011

dbSNP: rs2241766
rs2241766
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The rs266729 C allele and the rare minor alleles of rs2241766 and rs2082940 were associated with an increased adjusted hazard ratio of developing T2DM. 21219602

2011

dbSNP: rs1501299
rs1501299
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The presence of +45T>G (rs2241766), +276G>T (rs1501299) and -11391G>A (rs17300539) do not appear to influence the development of type 2 diabetes. 21638131

2011