|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
T2D risk was modeled using logistic regression with rs10830963 dosage, age, sex, and principal component as predictors.
|
29691896 |
2018 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations.
|
23456907 |
2014 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among single-nucleotide polymorphisms mostly associated with T2D risk, rs10830963 is located in the MTNR1B gene, encoding one of the two receptors of melatonin, a neurohormone involved in circadian rhythms.
|
29063374 |
2017 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
An association of the MTNR1B variant rs10830963 with T2D risk was not detected in our cohort.
|
24710643 |
2014 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association.
|
26551672 |
2015 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
|
28254843 |
2017 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
MTNR1B rs10830963 was genotyped in a population-based cohort including 3,210 unrelated Chinese Hans from Beijing and Shanghai, and tested for associations with risk of type 2 diabetes, diabetes-related traits and sleep status.
|
20398260 |
2010 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected.
|
26927145 |
2016 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings do not support participation of the MTNR1B gene variant rs10830963 in the well documented association between sleep disturbances and type 2 diabetes.
|
21380592 |
2011 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings indicated that MTNR1B rs10830963 variant might serve as a genetic biomarker of T2DM, especially in South Asians.
|
30811895 |
2019 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study shows that the diabetes risk variant rs10</span>830963 does not contribute to the known comorbidity between depression and type 2 diabetes.
|
30089436 |
2018 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01-1.08; OR, 1.08; 95%CI, 1.05-1.12 and OR, 1.05; 95%CI, 1.02-1.08, respectively).
|
23840762 |
2013 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between late chronotype and higher risk of T2D appears to vary across MTNR1B rs10830963 genotypes.
|
31623012 |
2020 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The associations of rs10830963 and rs1562444 with type 2 diabetes and related traits were not significant in the additive, dominant and recessive models.
|
21470412 |
2011 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common MTNR1B genetic variant rs10830963 is associated with an increased risk of type 2 diabetes (T2D).
|
26440713 |
2015 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G-allele of MTNR1B rs10830963 increases risk of type 2 diabetes through a state of i-IFG and not through i-IGT.
|
19324940 |
2009 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G-allele of the single nucleotide polymorphism (SNP) rs10830963 in MTNR1B (melatonin receptor 1B gene) is associated with type 2 diabetes mellitus and glucose levels in adults.
|
21366812 |
2011 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015).
|
19241057 |
2009 |
|
rs10830963
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The two polymorphisms were associated with FPG levels in the healthy individuals (P = 0.003 and P = 0.002, respectively), and the G allele of rs10830963 was also associated with an increased risk of Type 2 diabetes in our patient sample (odds ratio, 1.12; 95% confidence interval, 1.02-1.23; P = 0.024).
|
20536959 |
2010 |