Source: CLINVAR

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs587776805
rs587776805
ERBB2 ; MIR4728
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		GTGTGGGCTC 0.700 CausalMutation CLINVAR

dbSNP: rs397516975
rs397516975
ERBB2 ; MIR4728
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		AGCATACGTGATG 0.700 CausalMutation CLINVAR

dbSNP: rs1554350382
rs1554350382
EGFR ; EGFR-AS1
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		AGTC 0.700 GeneticVariation CLINVAR

dbSNP: rs121913469
rs121913469
ERBB2
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		CC 0.700 CausalMutation CLINVAR

dbSNP: rs121913366
rs121913366
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		C 0.700 CausalMutation CLINVAR

dbSNP: rs121913351
rs121913351
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		A 0.700 CausalMutation CLINVAR

dbSNP: rs1131692238
rs1131692238
CDK12
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR

dbSNP: rs1131692237
rs1131692237
ERBB2 ; MIR4728
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		G 0.700 CausalMutation CLINVAR

dbSNP: rs1057519788
rs1057519788
ROS1
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 CausalMutation CLINVAR

dbSNP: rs121913229
rs121913229
EGFR
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. 15737014

2005
dbSNP: rs1057520012
rs1057520012
EPHA5
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.800 GeneticVariation CLINVAR Somatic mutations of the protein kinase gene family in human lung cancer. 16140923

2005
dbSNP: rs121913315
rs121913315
STK11
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		A 0.700 GeneticVariation CLINVAR LKB1 modulates lung cancer differentiation and metastasis. 17676035

2007
dbSNP: rs1057520017
rs1057520017
STK11
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR LKB1 modulates lung cancer differentiation and metastasis. 17676035

2007
dbSNP: rs121913331
rs121913331
APC
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Somatic mutations affect key pathways in lung adenocarcinoma. 18948947

2008
dbSNP: rs150036236
rs150036236
EGFR
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		A 0.700 CausalMutation CLINVAR Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. 20942962

2010
dbSNP: rs863225281
rs863225281
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs863225281
rs863225281
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs1057519785
rs1057519785
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		C 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs1057519784
rs1057519784
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs1057519783
rs1057519783
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs1057519782
rs1057519782
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs1057519781
rs1057519781
ALK
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		G 0.700 GeneticVariation CLINVAR Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. 22277784

2012
dbSNP: rs121913355
rs121913355
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		G 0.700 GeneticVariation CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810

2012
dbSNP: rs1057519787
rs1057519787
ERBB2
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		A 0.700 GeneticVariation CLINVAR Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. 22908275

2012
dbSNP: rs1057519788
rs1057519788
ROS1
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		T 0.700 GeneticVariation CLINVAR Acquired resistance to crizotinib from a mutation in CD74-ROS1. 23724914

2013