|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The meta-analysis of the rs1333049 SNP in 12,0</span>04 cases and 28,949 controls increased the overall level of evidence for association with CAD to P=6.04x10(-10) (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29).
|
18362232 |
2008 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 2277 individuals, age 24 to 39 years, from the Cardiovascular Risk in Young Finns Study with CIMT and FMD measurements and 1295 individuals, age 46 to 76 years, from the Health 2000 Survey with CIMT for rs1333049, the chromosome 9p21 variant showing the strongest association with CAD.
|
18599798 |
2008 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan.
|
18675980 |
2009 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data from two populations show that variant rs1333049 is significantly associated with angiographically characterized CAD.
|
19135198 |
2009 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study.
|
19171343 |
2009 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
|
19548844 |
2009 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI).
|
20231156 |
2010 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In all, 950 patients with early onset CAD (age 56.1 +/- 9.6 years) and an independent sample of 764 patients with late onset CAD (age 70.0 +/- 8.0 years) were enrolled from the cardiac catheterization laboratories at the University of Ottawa Heart Institute from April 15, 2006, to August 15, 2008, and genotyped for the single nucleotide polymorphism rs1333049 9p21 risk variant.Angiographers were blinded to genotype.
|
20670758 |
2010 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrates a significant association of homozygous CC genotype of rs1333049 on chromosome 9p21.3 with CAD in Chinese Han population.
|
20691078 |
2010 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients.
|
21362310 |
2011 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD.
|
21558165 |
2011 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of 1095 CAD diagnosis-free participants, 52% were heterozygous (CG) and 22% were homozygous (CC) for the risk C allele rs1333049.
|
21852414 |
2011 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
To investigate whether the SNP rs1333049 located on the 9p21 chromosome is an independent risk factor for CAD in a Portuguese population.
|
21874923 |
2011 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI.
|
23729007 |
2013 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction.
|
23787071 |
2013 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined whether genotype at the lead CAD-associated single nucleotide polymorphism (rs1333049) in 9p21 was associated with: 1) basal levels of IFN-I in plasma from 148 healthy male subjects; 2) induction of IFN-I by Toll-like receptor stimulants in peripheral blood mononuclear cells of 60 healthy volunteers assessed by enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21 CAD risk region in reporter assays.
|
23933542 |
2013 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
|
rs1333049
|
|
Coronary Artery Disease
|
C |
0.900 |
GeneticVariation
|
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
849 CAD patients undergoing revascularization (660 with CAC and 189 without CAC) were enrolled in a cohort study to test its association with cardiovascular events in CAD patients with and without CAC in a 3-year follow-up. rs1333049 was significantly associated with the incidence of cardiovascular events in non-target vessels in patients with CAC (hazard ratio = 1.44, 95%CI, 1.08-1.91, P = 0.012), but not in those without CAC.
|
24732910 |
2014 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A replication study and a meta-analysis of the association between the CDKN2A rs1333049 polymorphism and coronary heart disease.
|
24930384 |
2014 |
|
rs1333049
|
|
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Higher FRS and PWV and the presence of rs2943634 risk allele were independent predictors of CAD (Nagelkerke R(2) 0·252, P < 0·001), while higher FRS and the presence of rs1333049 risk allele were independent predictors of multivessel CAD (Nagelkerke R(2) 0·190, P < 0·001).
|
24942486 |
2014 |