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rs1217691063
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|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
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16777985 |
2006 |
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rs1217691063
|
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer.
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22194208 |
2011 |
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rs1217691063
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Primary malignant neoplasm
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0.100 |
GeneticVariation
|
BEFREE |
To identify if methylene tetra-hydrofolatereductase (MTHFR) C677T polymorphisms are associated with oesophageal adenocarcinomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.
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25232254 |
2014 |
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rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) play an essential role in both DNA synthesis and methylation and polymorphisms in the MTHFR gene, 677C>T, 1298A>C and the MTRR gene, 66A>G, are associated with several types of malignancy.
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19035314 |
2008 |
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rs1217691063
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677C-->T polymorphism who have low status of methyl-related nutrients including folate.
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14608109 |
2003 |
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rs1217691063
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Some examples include the alanine-to-valine substitution at codon 222 (Ala222-->Val) [DNA: C-to-T substitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187-->Ser (DNA: 609C-->T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehy-drogenase (quinone)] and FAD (in relation to cancer), the Ala44-->Gly (DNA: 131C-->G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487-->Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer).
|
11916749 |
2002 |
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rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland.
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25966173 |
2015 |
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rs1217691063
|
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
The T allele of MTHFR C677T was significantly more frequently found in controls than in patients with cancer.
|
25075036 |
2014 |
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rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.
|
21848426 |
2012 |
|
rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer.
|
21732284 |
2011 |
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rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common MTHFR polymorphisms, C677T and A1298C, which lead to an altered amino acid sequence, have been associated with a decreased enzyme activity and susceptibility to cancer suggesting that these genetic variants may modulate the risk of several malignancies.
|
18781847 |
2008 |
|
rs1217691063
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
When MTHFR C677T genotype frequencies in MSS CRC cases were compared to controls, individuals with homozygous variant genotype were at 19% reduced risk of cancer compared to wild type (OR = 0.81; 95% CI: 0.65-1.02).
|
17350979 |
2007 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common polymorphisms are reported, C677T and A1298C, that are implicated in a number of human diseases, including cancer.
|
25921104 |
2015 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C-->T and 1298 A-->C have shown to impact several diseases including cancer.
|
20516537 |
2010 |
|
rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues.
|
23803092 |
2013 |
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rs1217691063
|
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Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T</span> homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
|
20473868 |
2011 |
|
rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Common methylenetetrahydrofolate reductase gene variants (MTHFR C677T and A1298C) have been described to have opposite effects on cancer patients.
|
17488658 |
2007 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
|
12175537 |
2002 |
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rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development.
|
26745044 |
2015 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate as a cancer-predisposing factor.
|
17712558 |
2007 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk.
|
18322814 |
2008 |
|
rs1217691063
|
|
Primary malignant neoplasm
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|
0.100 |
GeneticVariation
|
BEFREE |
Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.
|
22901194 |
2012 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been associated with many pathologies, including cancer.
|
31170928 |
2019 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters.
|
21180947 |
2011 |
|
rs1217691063
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
For children with malignancy, genotyping of the MTHFR C677T polymorphism is expected to be a useful tool in reducing toxicity and improving outcome in personalized MTX therapy.
|
28696419 |
2018 |