rs28897672
|
|
Malignant neoplasm of breast
|
C |
0.870 |
CausalMutation
|
CLINVAR |
|
|
|
rs55770810
|
|
Malignant neoplasm of breast
|
A |
0.810 |
CausalMutation
|
CLINVAR |
|
|
|
rs28897759
|
|
Malignant neoplasm of breast
|
T |
0.810 |
GeneticVariation
|
CLINVAR |
|
|
|
rs28897696
|
|
Malignant neoplasm of breast
|
T |
0.810 |
CausalMutation
|
CLINVAR |
|
|
|
rs200928781
|
|
Malignant neoplasm of breast
|
G |
0.810 |
GeneticVariation
|
CLINVAR |
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
|
25503501 |
2015 |
rs200928781
|
|
Malignant neoplasm of breast
|
G |
0.810 |
GeneticVariation
|
CLINVAR |
Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.
|
29922827 |
2018 |
rs200928781
|
|
Malignant neoplasm of breast
|
G |
0.810 |
GeneticVariation
|
CLINVAR |
Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity.
|
27553368 |
2016 |
rs200928781
|
|
Malignant neoplasm of breast
|
G |
0.810 |
GeneticVariation
|
CLINVAR |
Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.
|
27751358 |
2016 |
rs200928781
|
|
Malignant neoplasm of breast
|
G |
0.810 |
GeneticVariation
|
CLINVAR |
CHEK2 contribution to hereditary breast cancer in non-BRCA families.
|
22114986 |
2011 |
rs80359014
|
|
Malignant neoplasm of breast
|
T |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs80357389
|
|
Malignant neoplasm of breast
|
A |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs45580035
|
|
Malignant neoplasm of breast
|
T |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs41293511
|
|
Malignant neoplasm of breast
|
C |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs41293455
|
|
Malignant neoplasm of breast
|
A |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
|
11719428 |
2001 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Characterization of CHEK2 mutations in prostate cancer.
|
16835864 |
2006 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations and HNPCC-related colorectal cancer.
|
19876921 |
2010 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
|
18725978 |
2008 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
|
24880342 |
2014 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
The I157T variant may be associated with breast cancer risk, but the risk is lower than for 1100delC.
|
15239132 |
2004 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
|
11298456 |
2001 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
CHEK2 mutations and the risk of papillary thyroid cancer.
|
25583358 |
2015 |
rs17879961
|
|
Malignant neoplasm of breast
|
G |
0.800 |
GeneticVariation
|
CLINVAR |
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
|
22811390 |
2013 |