Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs380390
rs380390
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.810 GeneticVariation GWASDB Complement factor H polymorphism in age-related macular degeneration. 15761122

2005
dbSNP: rs11200638
rs11200638
HTRA1 ; LOC105378525
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.900 GeneticVariation GWASDB HTRA1 promoter polymorphism in wet age-related macular degeneration. 17053108

2006
dbSNP: rs10490924
rs10490924
ARMS2 ; LOC105378525
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB HTRA1 promoter polymorphism in wet age-related macular degeneration. 17053108

2006
dbSNP: rs2230199
rs2230199
C3
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.900 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		G 0.870 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs3764261
rs3764261
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.860 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs3793917
rs3793917
HTRA1 ; LOC105378525
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		G 0.840 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs2285714
rs2285714
PLA2G12A
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		T 0.810 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs9380272
rs9380272
C2 ; CYP21A2 ; C2-AS1
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.800 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs1329424
rs1329424
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		T 0.800 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs10737680
rs10737680
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.800 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs200483076
rs200483076
SYN3
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.700 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs641153
rs641153
CFB ; CYP21A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs2230199
rs2230199
C3
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs1410996
rs1410996
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs1061170
rs1061170
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs10490924
rs10490924
ARMS2 ; LOC105378525
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.890 GeneticVariation GWASDB Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258). 20385826

2010
dbSNP: rs10033900
rs10033900
CFI
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.840 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs11755724
rs11755724
RREB1
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		G 0.800 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs200483076
rs200483076
SYN3
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		A 0.700 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs800292
rs800292
CFH
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.900 GeneticVariation GWASDB Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010
dbSNP: rs2230199
rs2230199
C3
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.900 GeneticVariation GWASDB Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010