|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to a mild rise in plasma homocysteine levels and increase the incidence of coronary artery disease.
|
16489563 |
2006 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.
|
11096270 |
2001 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.
|
15648053 |
2006 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study extends previous observations by the finding that carriers of the N5,N10-methylenetetrahydrofolate reductase C677T TT genotype with various coronary high risk profiles had clearly higher coronary heart disease scores than individuals with at least one C677T C allele.
|
10337543 |
1999 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease.
|
27051002 |
2016 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
|
12049191 |
2002 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease.
|
14560345 |
2003 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with early onset of coronary artery disease in some populations with certain ethnic backgrounds.
|
18751630 |
2008 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
No strong evidence exists to support an association of the MTHFR 677 C-->T polymorphism and coronary heart disease in Europe, North America, or Australia.
|
16216822 |
2005 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).
|
15447919 |
2004 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease.
|
16274479 |
2005 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to mild hyperhomocysteinemia and, therefore, to the incidence of coronary artery disease.
|
11319193 |
2001 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
|
12522558 |
2003 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, traditionally associated with ischaemic heart disease (IHD), was assessed in a Spanish population.
|
12220440 |
2002 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
|
12387655 |
2002 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians.
|
26095803 |
2015 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians.
|
18075008 |
2007 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
|
24218123 |
2013 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contribute importantly to coronary artery disease.
|
8994411 |
1997 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.
|
18586656 |
2008 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.
|
17604826 |
2007 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
|
9806473 |
1998 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
|
18403793 |
2008 |
|
rs1217691063
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease.
|
14604831 |
2003 |