Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention. 18721847

2008
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed. 29414128

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. 20195291

2011
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response. 26976307

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide. 29432620

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls. 26117067

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Both clinical and pharmacological studies have implicated the common single nucleotide polymorphism (SNP) at position 196, Val66Met in the pathophysiology of major depressive disorder (MDD), and antidepressant response. 21188787

2011
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder. 20674983

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder. 17036259

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. 16979146

2006
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Effects of polymorphisms of serotonin transporter promoter (5-HTTLPR) and brain derived neurotrophic factor gene (G196A rs6265) on the risk of major depressive disorder in the Chinese Han population. 27212180

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia. 21129438

2011
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder. 20167454

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Moreover, there was no significant difference in normalized HCV between 5HTTLPR diallelic and triallelic classifications or between the BDNF Val66Met</span> genotypes in MDD patients, although there was a relationship between BDNF Val66Met and ICV. 21692988

2011
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients. 19493959

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. 18852698

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males. 22033217

2012
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. 22585743

2012
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD. 22883353

2012
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. 17401528

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Significant associations between AD and MDD have been found for three polymorphisms mainly in females (TPH1 A218C, MAOA VNTR and BDNF Val66Met) and one polymorphism in the total population only (FKBP5 rs1360780). 23157339

2013
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Significant interactions between the Val66Met polymorphism and 3 clinical characteristics - age at onset (p = 0.03), MDD duration (p = 0.04), and number of previous MDE (p = 0.04) - were evidenced for plasma BDNF levels. 28848102

2017
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE Taken together, we did not detect any plausible evidence regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD. 29387021

2017