|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of SKIV2L rs429608 with neovascular AMD remained significant after adjusting for CFH rs800292 and HTRA1 rs11200638.
|
23260260 |
2013 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Contrary to previous reports, we show that rs11200638 SNP has no significant impact on HTRA1 promoter activity in three different cell lines, and HTRA1 mRNA expression exhibits no significant change between control and AMD retinas.
|
17884985 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Eight single nucleotide polymorphisms (SNPs) from 6 genes of the HDL metabolism pathway and 2 known AMD-associated SNPs, rs800292 (from complement factor H [CFH]) and rs11200638 (from HtrA serine peptidase 1 [HTRA1]), were genotyped in all study subjects using the TaqMan genotyping technology (Applied Biosystems, Foster City, CA).
|
24393350 |
2014 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Rs12153855C and rs9391734A alleles could further increase the susceptibility to AMD in subjects with rs800292, rs11200638 and rs429608 risk alleles.
|
26861912 |
2016 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Mapping the genes for age-related macular degeneration (AMD) had not been successful until recent genome-wide association studies revealed Tyr402His in CFH and rs11200638 in HTRA1 as AMD-related genetic variants.
|
18316707 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were detected for exudative AMD with SNPs rs10490924:G>T in LOC387715 (A69S), and rs11200638:G>A in the promoter of HTRA1.
|
18682812 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The allele/genotype frequencies of CFH rs1061170 and HTRA1 rs11200638, two well-confirmed AMD-susceptible SNPs, were close to each other in the Han Chinese and Japanese population.
|
21609242 |
2011 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD).
|
20664794 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, recent reports have shown that the rs11200638, a single nucleotide polymorphism (SNP) in the promoter region of the HTRA1 gene, is strongly associated with an increased prevalence of age-related macular degeneration (AMD).
|
19798546 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study strengthens the hypothesis of association between rs11200638</span> in the promoter of HTRA1 polymorphism and AMD.
|
19026638 |
2009 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The findings indicate that the intergenic region between the tSNP rs3793917 and the SNP rs11200638 in the HTRA1 gene is the most likely site explaining the significant association with AMD.
|
20445115 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygotes for the risk allele at rs11200638 had a 6.33-fold increased risk of PCV and a 13.77-fold increased risk of wet AMD when compared with homozygotes for the wild-type allele.
|
17692272 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The HTRA1 promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular AMD.
|
17438519 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk variants in rs1061170 (CFH) and rs11200638 (HTRA1).
|
25627090 |
2015 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genotypes were compared using chi square analysis for an additive allelic model. rs11200638 was significantly associated with wet AMD (p=5.00x10(-12)).
|
17904186 |
2007 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first time the association between rs11200638 and overall age-related macular degeneration has been reported in South America.
|
28846052 |
2018 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant association was noted in CFH-rs800292, CFH-rs1410996, CFH-rs2274700, and HTRA1-rs11200638 with AMD development (P = 2.36x10(-5), 7.18x10(-5), 7.18x10(-5), 2.70x10(-7), respectively; population attributable risk = 57.3%, 57.8%, 57.8%, and 58.9%, respectively).
|
20132989 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.
|
31583032 |
2019 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Purpose.To determine the relationship of six genetic variants (rs10490924, rs3750848, del443ins54, rs3793917, rs11200638, and rs932275) localized to the ARMS2-HTRA1 region of chromosome 10, region q26, as risk factors for age-related macular degeneration (AMD), to define the haplotype structure of these six loci, and to confirm their genetic association with the disease.Methods.
|
19933195 |
2010 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
We demonstrate that rs1120</span>0638 in the promoter region and rs2293870 in exon 1 of HTRA1, are among the most significantly associated variants for advanced forms of AMD.
|
18207215 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs11200638
|
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Subject I:2 with AMD carried both at-risk genotypes at HTRA1 rs11200638 and CFH rs800292.
|
19933189 |
2010 |