Source: GWASCAT

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.810 GeneticVariation GWASCAT New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. 23575436

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio 		T 0.800 GeneticVariation GWASCAT For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 x 10(-12)) showed convincing associations, although no regional transcript has strong biological candidacy. 19396169

2009
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0005845
Disease: Blood urea nitrogen measurement
Blood urea nitrogen measurement 		A 0.800 GeneticVariation GWASCAT Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. 22797727

2012
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		T 0.800 GeneticVariation GWASCAT Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. 21270382

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASCAT Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. 21909109

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASCAT The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits. 30718733

2019
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		T 0.800 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		A 0.800 GeneticVariation GWASCAT Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. 28485404

2017
dbSNP: rs11066280
rs11066280
HECTD4
CUI: C0013124
Disease: Drinking behavior processes
Drinking behavior processes 		T 0.800 GeneticVariation GWASCAT The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P < 5 × 10(-8)), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 × 10(-215)). 23364009

2013
dbSNP: rs11066280
rs11066280
HECTD4
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		A 0.800 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993

2011
dbSNP: rs11066280
rs11066280
HECTD4
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		A 0.800 GeneticVariation GWASCAT Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. 22751097

2012
dbSNP: rs11066280
rs11066280
HECTD4
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		T 0.710 GeneticVariation GWASCAT Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. 25249183

2015
dbSNP: rs7953257
rs7953257
HECTD4
CUI: C1305849
Disease: Diastolic blood pressure measurement
Diastolic blood pressure measurement 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962

2018
dbSNP: rs7953257
rs7953257
HECTD4
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962

2018
dbSNP: rs7953257
rs7953257
HECTD4
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962

2018
dbSNP: rs7953257
rs7953257
HECTD4
CUI: C0428886
Disease: Mean blood pressure
Mean blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962

2018
dbSNP: rs7953257
rs7953257
HECTD4
CUI: C0428883
Disease: Diastolic blood pressure
Diastolic blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962

2018
dbSNP: rs77768175
rs77768175
HECTD4
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		G 0.700 GeneticVariation GWASCAT The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits. 30718733

2019
dbSNP: rs555346412
rs555346412
HECTD4
CUI: C0857490
Disease: Granulocyte count
Granulocyte count 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs555346412
rs555346412
HECTD4
CUI: C0200633
Disease: Neutrophil count (procedure)
Neutrophil count (procedure) 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs555346412
rs555346412
HECTD4
CUI: C0200641
Disease: Blood basophil count (lab test)
Blood basophil count (lab test) 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs555346412
rs555346412
HECTD4
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs555346412
rs555346412
HECTD4
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252

2016
dbSNP: rs4766898
rs4766898
HECTD4
CUI: C0202239
Disease: Uric acid measurement (procedure)
Uric acid measurement (procedure) 		T 0.700 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528

2019
dbSNP: rs2301712
rs2301712
HECTD4
CUI: C1305855
Disease: Body mass index
Body mass index 		G 0.700 GeneticVariation GWASCAT Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. 28892062

2017