rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
|
|
|
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
<i>IDH1</i> mutations only affected brainstem gliomas (6/24 vs 0/78; <i>p</i> = 7.5 × 10<sup>-5</sup>), were mostly non-R132H (contrasting with hemispheric gliomas, <i>p</i> = 0.0001), and were associated with longer survival (54 vs 12 months).
|
29728520 |
2018 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Activated leukocyte adhesion molecule expression in gliomas was independent of proliferative activity, MGMT status, patient survival, and age, whereas gliomas with IDH1 (R132H) mutation had significantly higher activated leukocyte adhesion molecule levels than their wild-type counterparts.
|
22304788 |
2012 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Additionally, 5-aza enhances the therapeutic effect of the DNA damaging agent TMZ in both subcutaneous and orthotopic PDX models of IDH1 R132H mutant glioma.
|
30184215 |
2019 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Although there are many changes of genes in tumour malignant progression, IDH1 R132H mutation status in glioma progression remained unclear.
|
28928859 |
2017 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
As IDH1(R132H) is present in all tumour cells of these slow-growing gliomas, a mutation-specific anti-IDH1(R132H) vaccine may represent a viable novel therapeutic strategy for IDH1(R132H)-mutated tumours.
|
25043048 |
2014 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
|
31292202 |
2019 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Double staining for IDH1-R132H and Ki-67 demonstrated that most invading cells that expressed IDH1-R132H were not stained by the Ki-67 antibody, and the ratio of Ki-67-positive cells among IDH1-R132H-positive cells was significantly lower in the invasion area than in the tumor core in all grades of glioma.
|
24384677 |
2014 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
For this study, 164 cases of glioma were evaluated immunohistochemically for IDH1 mutations (R132H and R132S) using anti-IDH1 mAbs (HMab-1 and SMab-1).
|
22396072 |
2012 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Further, overexpression of β-catenin in IDH1-R132H glio</span>ma cells restored the cellular phenotype induced by this mutation.
|
26860959 |
2016 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Gliomas were analyzed for MGMT methylation, glioma CpG island methylator phenotype and IDH1 R132H.
|
27337298 |
2016 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, we describe the isolation of a glioma brain tumor stem cell line (BT142) with an endogenous R132H mutation in IDH1, aggressive tumor-initiating capacity, and 2-HG production.
|
22166263 |
2012 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway.
|
28427200 |
2017 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IDH1(R132H) mutation increases U87 glioma cell sensitivity to radiation therapy in hypoxia.
|
24895549 |
2014 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
|
30760578 |
2019 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
If a glioma is weakly positive for mIDH1(R132H), immunohistochemistry for RcMab-1 should be performed.
|
26006098 |
2015 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In 1 case, an IDH1 R132H-mutant glioma was misdiagnosed as a demyelinating condition by frozen section histology during the intraoperative consultation, and no resection was performed pending the final pathology report.
|
30611146 |
2019 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In cases tested by DNA sequencing, the fraction of non-R132H mutations was 5.4%, which included only 2 high-grade gliomas in patients ≥55 years (0.9%).
|
29016871 |
2017 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the association of a C-terminally truncated form of αB-crystallin protein with the IDH1(R132H) mutation is a novel finding that could impact apoptosis and stress response in IDH1 mutant glioma.
|
24473683 |
2014 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, we established an anti-IDH1(R132H)-specific monoclonal antibody IMab-1, which should be significantly useful for diagnosis and biological evaluation of mutation-bearing gliomas.
|
19818334 |
2009 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this study, we generated clonal U87 and U251 glioma cell lines overexpressing the R132H mutant protein (IDH1-R132H).
|
25283382 |
2015 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Interestingly, non-p.R132H mutations segregate in distinct histological and molecular subtypes of glioma.
|
20077503 |
2010 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Isocitrate dehydrogenase (IDH) mutations, particularly IDH1 R132H (G395A), are found in WHO Grade II and III diffuse gliomas as well as secondary, but not primary, glioblastomas.
|
22385787 |
2012 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations.
|
28445981 |
2017 |
rs121913500
|
|
Glioma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Mutations in the isocitrate dehydrogenase (IDH) 1 gene are commonly found in human glioma, with the majority of low-grade gliomas harboring a recurrent point mutation (IDH1 R132H).
|
31768950 |
2019 |