|
rs1800795
|
|
Uveitis, Intermediate
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11).
|
26640809 |
2015 |
|
rs1800795
|
|
Uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p > 0.05).
|
26640809 |
2015 |
|
rs777906302
|
|
Urinary tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type.
|
30335568 |
2019 |
|
rs1800795
|
|
Urinary tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations were found between the CC genotype of IL6 SNP rs1800795 and occurrence of bacteremia and between TLR5 SNP rs5744168 and protection from UTI.
|
25807366 |
2015 |
|
rs2069837
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found correlations between one SNP in IL6 (rs2069837 <i>p</i> = 6.63E-11), seven SNPs in <i>IL10</i> (rs1554286 <i>p</i> = 6.87E-20, rs1518111 <i>p</i> = 6.11E-11, rs3021094 <i>p</i> = 6.75E-29, rs3790622 <i>p</i> = 2.40E-06, rs3024490 <i>p</i> = 6.73E-11, rs1800872 <i>p</i> = 6.18E-11, rs1800871 <i>p</i> = 6.73E-11) and incidences of PTB.
|
29662655 |
2018 |
|
rs1800795
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility.
|
26840977 |
2016 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31676365 |
2020 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
|
rs1800796
|
|
Tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children.
|
30029918 |
2018 |
|
rs1800796
|
|
Tuberculosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870).
|
22457277 |
2012 |
|
rs2069837
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele at rs2069837 of IL6 was significantly more common in controls than in TB patients in the Han population.
|
30792445 |
2019 |
|
rs1800797
|
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome.
|
28829905 |
2017 |
|
rs1524107
|
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome.
|
20186139 |
2010 |
|
rs1800796
|
|
Tooth Loss
|
|
0.010 |
GeneticVariation
|
BEFREE |
To examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss.
|
26011111 |
2015 |
|
rs1800795
|
|
Tinnitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found significant association between the genotype and allele frequencies of the IL6 -174 gene (rs1800795) and tinnitus among the elderly with history of exposure to occupational noise (P = 0.03).
|
26572700 |
2016 |
|
rs1800796
|
|
Thrombosis of cerebral veins
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
rs1800795
|
|
Thrombosis of cerebral veins
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
GWASCAT |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G).
|
31315839 |
2019 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs1800795
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
|
rs2069840
|
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs</span>2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).
|
23027890 |
2012 |
|
rs2069827
|
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).
|
23027890 |
2012 |