|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31676365 |
2020 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
|
rs1800796
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Relationship between polymorphisms in -572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta-analysis.
|
31782615 |
2020 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G).
|
31315839 |
2019 |
|
rs2069837
|
|
Longevity
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
A meta-analysis of genome-wide association studies identifies multiple longevity genes.
|
31413261 |
2019 |
|
rs1474348
|
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
|
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
|
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
|
rs1800795
|
|
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings indicated that IL-6 rs1800795 polymorphism was significantly associated with individual susceptibility to IS in Asians, but not in Caucasians.
|
31446341 |
2019 |
|
rs1800796
|
|
Stomach Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
rs1800796
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk.
|
31301734 |
2019 |
|
rs1800796
|
|
Malignant neoplasm of stomach
|
|
0.040 |
GeneticVariation
|
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
|
rs1800795
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
|
rs1800796
|
|
Sleep Apnea, Obstructive
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10-2.04; p = 0.010), IL-6 rs1800796 (OR = 1.32, 95% CIs = 1.11-1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13-1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04-1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18-2.62; p = 0.006), IL-6 rs1800796 (OR = 1.39, 95% CIs = 1.10-1.76; p = 0.006) were associated with the severity of OSA.
|
31210414 |
2019 |
|
rs1800796
|
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk.
|
31301734 |
2019 |
|
rs1800796
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs1800795
|
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor alleles of rs1800795 raised and rs1800797 reduced the risk of obesity, while rs1800796 and rs2069845 may not be associated.
|
31472475 |
2019 |
|
rs1800795
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs1800795
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
|
Gestational Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the correlations and interactions between the polymorphisms of insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related genes (GNB3 rs5443, ADRB rs1042714), and risk factors for gestational diabetes mellitus (GDM) such as diet structure in the development of GDM.
|
29519182 |
2019 |
|
rs1800795
|
|
Cerebral Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further subgroup analyses showed that IL-6 rs1800795 was significantly associated with IS in Asians in GG versus GC + CC (dominant model, p = .0005, OR = 0.74, 95%CI 0.62-0.88), CC versus GG + GC (recessive model, p = .003, OR = 1.61, 95%CI 1.17-2.21) and G versus C (allele model, p = .01, OR = 0.74, 95%CI 0.58-0.93), whereas IL-10 rs1800896 polymorphism was significantly associated with cerebral infarction (CI) in GG versus GA + AA (dominant model, p = .02, OR = 2.04, 95%CI 1.14-3.64), GA versus GG + AA (overdominant model, p = .03, OR = 0.50, 95%CI 0.27-0.93) and G versus A (allele model, p = .01, OR = 1.92, 95%CI 1.16-3.17).
|
31446341 |
2019 |
|
rs1800795
|
|
Irritable Bowel Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Ten relevant genes were evaluated.SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients.
|
31615448 |
2019 |