Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation GWASCAT We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015

dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation BEFREE We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015

dbSNP: rs2069837
rs2069837
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.720 GeneticVariation BEFREE Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G). 31315839

2019

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation GWASCAT A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. 26545630

2016

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold. 22015309

2012

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD. 26733302

2016

dbSNP: rs2069837
rs2069837
CUI: C0023980
Disease: Longevity
Longevity
A 0.700 GeneticVariation GWASCAT Novel loci and pathways significantly associated with longevity. 26912274

2016

dbSNP: rs2069837
rs2069837
CUI: C0023980
Disease: Longevity
Longevity
A 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261

2019

dbSNP: rs1474348
rs1474348
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs13306436
rs13306436
IL6
High density lipoprotein measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. 17003362

2006

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. 18752089

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes. 19140096

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus. 22075267

2012

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes. 25222779

2014

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein. 28651253

2017

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE An association of the rs1800795 SNP of the IL-6 gene with T2D has been detected for the first time in Cretans. 29957071

2018

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250

2009

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297

2014

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651

2015

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724

2017

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725

2018

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa risk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492

2019