|
rs13306435
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study.
|
21633598 |
2011 |
|
rs1474347
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively).
|
25030201 |
2014 |
|
rs1474348
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1474348
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1474348
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1524107
|
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, four variations (rs1800796, rs1524107, rs2069840, rs2243250) of the selected candidate SNPs were associated with susceptibility to LDD in our study.
|
29179499 |
2017 |
|
rs1524107
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes.
|
27500547 |
2016 |
|
rs1524107
|
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes.
|
27500547 |
2016 |
|
rs1524107
|
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome.
|
20186139 |
2010 |
|
rs1554606
|
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant correlations were found when analyzing the association of rs1800795 and rs1554606 with OST risk.
|
31301734 |
2019 |
|
rs1554606
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population.
|
24395296 |
2014 |
|
rs1800795
|
|
Optic Neuritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, <i>IL6</i> rs1800795 G/G genotype was associated with increased odds of ON development under the codominant (OR = 2.869;95%CI:1.280-6.434) and recessive (OR = 2.315;95%CI:1.251-4.285) models.
|
31199170 |
2019 |
|
rs1800795
|
|
Proliferative vitreoretinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences in genotype distributions between patients with RRD with or without PVR were detected in rs1800795 (IL6) (P = 0.04), rs1800871 (in the vicinity of the IL10) (P = 0.034), and rs1800471 (TGFB1) (P = 0.032).
|
30807515 |
2019 |
|
rs1800795
|
|
Benign Prostatic Hyperplasia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A C haplotype (rs2069845 and rs1800795 respectively) was associated with PCa and BPH risk (OR (95% CI) = 1.67 (1.12- 2.48); OR (95% CI)= 1.78 (1.25 - 2.54)).
|
30345492 |
2019 |
|
rs1800795
|
|
Experimental Organism Basal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004).
|
31342143 |
2019 |
|
rs1800795
|
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML.
|
31373163 |
2019 |
|
rs1800795
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>IL-6</i> rs1800795 (-174 G>C) and <i>MMP-13</i> rs2252070 (-77G>A) mutations were associated with KOA susceptibility, increased disease severity, and up-regulation of IL-6 and MMP-13 expression levels.
|
30635366 |
2019 |
|
rs1800795
|
|
Carcinoma, Basal Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004).
|
31342143 |
2019 |
|
rs1800795
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study.
|
31338006 |
2019 |
|
rs1800795
|
|
Stomach Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms.
|
30525242 |
2019 |
|
rs1800795
|
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using robust data, we found that <i>IL-6</i> (rs1800795) -174<i>G>C</i> gene polymorphism is associated with CVD risk.
|
31338006 |
2019 |
|
rs1800795
|
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals.
|
31291232 |
2019 |
|
rs1800795
|
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |