Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13306435
rs13306435
IL6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. 21633598

2011

dbSNP: rs1474347
rs1474347
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively). 25030201

2014

dbSNP: rs1474348
rs1474348
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1474348
rs1474348
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1474348
rs1474348
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1524107
rs1524107
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 GeneticVariation BEFREE We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ). 30828987

2019

dbSNP: rs1524107
rs1524107
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.010 GeneticVariation BEFREE We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ). 30828987

2019

dbSNP: rs1524107
rs1524107
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.010 GeneticVariation BEFREE In summary, four variations (rs1800796, rs1524107, rs2069840, rs2243250) of the selected candidate SNPs were associated with susceptibility to LDD in our study. 29179499

2017

dbSNP: rs1524107
rs1524107
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes. 27500547

2016

dbSNP: rs1524107
rs1524107
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 GeneticVariation BEFREE IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes. 27500547

2016

dbSNP: rs1524107
rs1524107
CUI: C1857276
Disease: Trichohepatoenteric Syndrome
Trichohepatoenteric Syndrome
0.010 GeneticVariation BEFREE We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome. 20186139

2010

dbSNP: rs1554606
rs1554606
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.010 GeneticVariation BEFREE However, no significant correlations were found when analyzing the association of rs1800795 and rs1554606 with OST risk. 31301734

2019

dbSNP: rs1554606
rs1554606
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation BEFREE The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population. 24395296

2014

dbSNP: rs1800795
rs1800795
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.010 GeneticVariation BEFREE Using robust data, we found that <i>IL-6</i> (rs1800795) -174<i>G>C</i> gene polymorphism is associated with CVD risk. 31338006

2019

dbSNP: rs1800795
rs1800795
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. 31338006

2019

dbSNP: rs1800795
rs1800795
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.010 GeneticVariation BEFREE We aimed to evaluate the multivariate effect of TNF-α rs361525, rs1800750, rs1800629, IL-10 rs1800896, rs1800872, IL-6 rs1800795, TGF-β1 rs1800470, IFN-γ rs2430561 single nucleotide polymorphisms (SNPs) on AML risk, the multivariate effect of SNPs on overall survival (OS) in AML and the association between the investigated SNPs and prognostic factors in AML. 31373163

2019

dbSNP: rs1800795
rs1800795
CUI: C0029134
Disease: Optic Neuritis
Optic Neuritis
0.010 GeneticVariation BEFREE Furthermore, <i>IL6</i> rs1800795 G/G genotype was associated with increased odds of ON development under the codominant (OR = 2.869;95%CI:1.280-6.434) and recessive (OR = 2.315;95%CI:1.251-4.285) models. 31199170

2019

dbSNP: rs1800795
rs1800795
CUI: C0038354
Disease: Stomach Diseases
Stomach Diseases
0.010 GeneticVariation BEFREE In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. 30525242

2019

dbSNP: rs1800795
rs1800795
CUI: C0038436
Disease: Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder
0.010 GeneticVariation BEFREE Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals. 31291232

2019

dbSNP: rs1800795
rs1800795
CUI: C0242852
Disease: Proliferative vitreoretinopathy
Proliferative vitreoretinopathy
0.010 GeneticVariation BEFREE Differences in genotype distributions between patients with RRD with or without PVR were detected in rs1800795 (IL6) (P = 0.04), rs1800871 (in the vicinity of the IL10) (P = 0.034), and rs1800471 (TGFB1) (P = 0.032). 30807515

2019

dbSNP: rs1800795
rs1800795
CUI: C0409959
Disease: Osteoarthritis, Knee
Osteoarthritis, Knee
0.010 GeneticVariation BEFREE The <i>IL-6</i> rs1800795 (-174 G>C) and <i>MMP-13</i> rs2252070 (-77G>A) mutations were associated with KOA susceptibility, increased disease severity, and up-regulation of IL-6 and MMP-13 expression levels. 30635366

2019

dbSNP: rs1800795
rs1800795
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia
0.010 GeneticVariation BEFREE The A C haplotype (rs2069845 and rs1800795 respectively) was associated with PCa and BPH risk (OR (95% CI) = 1.67 (1.12- 2.48); OR (95% CI)= 1.78 (1.25 - 2.54)). 30345492

2019

dbSNP: rs1800795
rs1800795
Experimental Organism Basal Cell Carcinoma
0.010 GeneticVariation BEFREE We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004). 31342143

2019

dbSNP: rs1800795
rs1800795
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell
0.010 GeneticVariation BEFREE We have found that the presence of C allele in rs1800795 IL-6 gene polymorphism was associated with increased risk of BCC (aOR 1.86; 95% CI 1.22-2.84; p = 0.004). 31342143

2019

dbSNP: rs1800795
rs1800795
CUI: C0003164
Disease: Anthracosilicosis
Anthracosilicosis
0.010 GeneticVariation BEFREE Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects. 29378067

2018