Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 GeneticVariation BEFREE Hypertension significantly modified the association between rs2069837 polymorphisms and the risk of LOAD (pinteraction = 0.03). 22272811

2012
dbSNP: rs1800796
rs1800796
IL6 ; STEAP1B ; IL6-AS1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.020 GeneticVariation BEFREE rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children. 30029918

2018
dbSNP: rs1800796
rs1800796
IL6 ; STEAP1B ; IL6-AS1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.010 GeneticVariation BEFREE rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children. 30029918

2018
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0023980
Disease: Longevity
Longevity 		A 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261

2019
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.720 GeneticVariation GWASCAT A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. 26545630

2016
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 GeneticVariation BEFREE A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele. 19585495

2009
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 GeneticVariation BEFREE A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele. 19585495

2009
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 GeneticVariation BEFREE A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele. 19585495

2009
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy 		0.020 GeneticVariation BEFREE A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions. 24314052

2013
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0221505
Disease: Lesion of brain
Lesion of brain 		0.010 GeneticVariation BEFREE A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions. 24314052

2013
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.010 GeneticVariation BEFREE AA genotype in rs1800797 of IL-6 was associated with the increased risk of developing AR. 24974143

2014
dbSNP: rs777906302
rs777906302
IL6 ; IL6-AS1
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.010 GeneticVariation BEFREE Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type. 30335568

2019
dbSNP: rs777906302
rs777906302
IL6 ; IL6-AS1
CUI: C0262655
Disease: Recurrent urinary tract infection
Recurrent urinary tract infection 		0.010 GeneticVariation BEFREE Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type. 30335568

2019
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma 		0.010 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.010 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.010 GeneticVariation BEFREE Additionally, rs2069837 variant elevated the PTC risk based on dominant model (p = 0.041). 31288714

2019
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 GeneticVariation BEFREE Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. 31338006

2019
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.020 GeneticVariation BEFREE Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. 31338006

2019
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.010 GeneticVariation BEFREE Additionally, we found that carriers of the <i>C</i> allele of 174<i>G>C</i> (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. 31338006

2019
dbSNP: rs1800796
rs1800796
IL6 ; STEAP1B ; IL6-AS1
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.040 GeneticVariation BEFREE After adjusting for age, the IL6 -634G > C (rs1800796) allele showed association with osteoporosis (odds ratio (OR) for CC + CG = 2.51, p = 0.0047)), independent of statin use or smoking status. 19506792

2010
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
CUI: C0038436
Disease: Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder 		0.010 GeneticVariation BEFREE Although our nominally significant results did not withstand correction for multiple tests they may support a relevance of the COMT (Val158Met) and IL6 rs1800795 polymorphism for aspects of PTSD in war traumatized individuals. 31291232

2019
dbSNP: rs2069832
rs2069832
IL6 ; IL6-AS1
CUI: C0242966
Disease: Systemic Inflammatory Response Syndrome
Systemic Inflammatory Response Syndrome 		0.010 GeneticVariation BEFREE Among Caucasian subjects with SIRS (n = 750), we identified a nominal association between rs2069832 in IL6 and ALI susceptibility (OR(adj) 1.61; 95% confidence interval [CI], 1.04-2.48, P = 0.03). 23251429

2012
dbSNP: rs1800797
rs1800797
IL6 ; STEAP1B ; IL6-AS1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively). 17416766

2007