Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13306436
rs13306436
IL6
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs13306436
rs13306436
IL6
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs13306436
rs13306436
IL6
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs369953112
rs369953112
IL6
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.010 GeneticVariation BEFREE The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. 21749608

2011
dbSNP: rs2069861
rs2069861
IL6
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE There was a significantly increased risk of breast cancer associated with one or more C>T alleles at IL6 rs2069861 among subjects in the oldest age group (OR 1.8, 95% CI 1.1-2.9), but no overall increased risk of breast cancer associated with any IL6 or IL6R variants in the combined data. 21523452

2011
dbSNP: rs2069861
rs2069861
IL6
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 GeneticVariation BEFREE There was a significantly increased risk of breast cancer associated with one or more C>T alleles at IL6 rs2069861 among subjects in the oldest age group (OR 1.8, 95% CI 1.1-2.9), but no overall increased risk of breast cancer associated with any IL6 or IL6R variants in the combined data. 21523452

2011
dbSNP: rs2069849
rs2069849
IL6
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.010 GeneticVariation BEFREE Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk. 31301734

2019
dbSNP: rs2069849
rs2069849
IL6
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation BEFREE Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk. 31301734

2019
dbSNP: rs2069849
rs2069849
IL6
CUI: C4049006
Disease: Selective immunoglobulin A deficiency
Selective immunoglobulin A deficiency 		0.010 GeneticVariation BEFREE We observed an increased frequency of the -174C allele in IgAD patients (p = 0.005, odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.12-2.04) and a protective effect of the rs2069849_C allele (p = 0.007, odds ratio = 0.29, 95% CI = 0.09-0.76). 18486766

2008
dbSNP: rs2069845
rs2069845
IL6
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation BEFREE In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. 30269203

2018
dbSNP: rs2069845
rs2069845
IL6
CUI: C1704272
Disease: Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia 		0.010 GeneticVariation BEFREE The A C haplotype (rs2069845 and rs1800795 respectively) was associated with PCa and BPH risk (OR (95% CI) = 1.67 (1.12- 2.48); OR (95% CI)= 1.78 (1.25 - 2.54)). 30345492

2019
dbSNP: rs2069845
rs2069845
IL6
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017
dbSNP: rs2069845
rs2069845
IL6
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 GeneticVariation BEFREE However, the frequency of rs</span>2069845 variants was not significantly different between PCa, BPH and control groups. 30345492

2019
dbSNP: rs2069845
rs2069845
IL6
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017
dbSNP: rs2069845
rs2069845
IL6
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation BEFREE In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. 30269203

2018
dbSNP: rs2069845
rs2069845
IL6
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE However, the frequency of rs</span>2069845 variants was not significantly different between PCa, BPH and control groups. 30345492

2019
dbSNP: rs2069845
rs2069845
IL6
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017
dbSNP: rs2069843
rs2069843
IL6
CUI: C0017677
Disease: Glossitis, Benign Migratory
Glossitis, Benign Migratory 		0.010 GeneticVariation BEFREE IL6 allele G rs2069843 polymorphism was associated with BMG in the dominant model. 27810384

2017
dbSNP: rs13306435
rs13306435
IL6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. 21633598

2011
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.720 GeneticVariation GWASCAT We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.720 GeneticVariation BEFREE Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G). 31315839

2019
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.720 GeneticVariation BEFREE We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). 25604533

2015
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0023980
Disease: Longevity
Longevity 		A 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies multiple longevity genes. 31413261

2019
dbSNP: rs2069837
rs2069837
IL6 ; IL6-AS1
CUI: C0023980
Disease: Longevity
Longevity 		A 0.700 GeneticVariation GWASCAT Novel loci and pathways significantly associated with longevity. 26912274

2016
dbSNP: rs1474348
rs1474348
IL6 ; IL6-AS1
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019