|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Given that <i>TOX3</i> mRNA is a target of miR-182, and that both the <i>TOX3</i> rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect.
|
30135399 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer.
|
24069142 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls.
|
29683073 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conclusively, this meta-analysis suggests that TNRC9 rs3803662 polymorphism was significantly correlated with breast cancer risk and the variant T allele of TNRC9 rs3803662 polymorphism is a low-penetrant risk factor for developing breast cancer.
|
20703937 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.
|
27350156 |
2016 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations with BC were observed for rs3803662 (dominant comparison: OR, 0.89; 95% CI, 0.84-0.95; P = .0008; recessive comparison: OR, 1.17; 95% CI, 1.07-1.28; P = .0004; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .002; allele comparison: OR, 0.90; 95% CI, 0.86-0.95; P = .0002), rs8051542 (dominant comparison: OR, 0.87; 95% CI, 0.83-0.91; P < .0001; recessive comparison: OR, 1.19; 95% CI, 1.11-1.28; P < .0001; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .004; allele comparison: OR, 0.89; 95% CI, 0.86-0.91; P < .0001), and rs12922061 (dominant comparison: OR, 0.83; 95% CI, 0.73-0.93; P = .002; over-dominant comparison: OR, 1.43; 95% CI, 1.27-1.61; P < .0001) polymorphisms in the overall population.
|
31324582 |
2019 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two index SNPs were associated with breast cancer: rs3803662 at 16q12.2/TOX3 (Hazard ratio [HR] for the T allele = 0.79, 95% CI: 0.67-0.92, P = 0.003) and rs10941679 at 5p12 (HR for the G allele = 1.31, 95% CI: 1.06-1.63, P = 0.014).
|
21795501 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the exception of rs3803662 (TOX3), there was no evidence that any of the SNPs associated with BC susceptibility were associated with the BC survival.
|
22532573 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The known breast cancer SNPs rs13281615, rs2981582 and rs3803662 were confirmed as associated with breast cancer risk (P (allelic test) = 1.8 x 10(-2), OR = 1.17; P (allelic test) = 2.2 x 10(-3), OR = 1.22; P (allelic test) = 5.1 x 10(-2), OR = 1.15, respectively) in the West of Ireland cohort.
|
19005751 |
2009 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that the effect of the risk allele of rs3803662 is strongest in luminal A tumours and that the expression levels of TOX3 and/or LOC643714 affect the progression of breast cancer.
|
23270421 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor alleles of SNP rs2981582 and rs889312 were each associated with increased breast cancer risk in BRCA2 mutation carriers (per-allele hazard ratio [HR] = 1.32, 95% CI: 1.20-1.45, p(trend) = 1.7 x 10(-8) and HR = 1.12, 95% CI: 1.02-1.24, p(trend) = 0.02) but not in BRCA1 carriers. rs3803662 was associated with increased breast cancer risk in both BRCA1 and BRCA2 mutation carriers (per-allele HR = 1.13, 95% CI: 1.06-1.20, p(trend) = 5 x 10(-5) in BRCA1 and BRCA2 combined).
|
18355772 |
2008 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
None of the three polymorphisms was significantly associated with breast cancer risk in the whole data set (P = 0.151, 0.644, and 0.737 for rs3803662, rs12443621. and rs8051542, respectively).
|
20213080 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs3803662 single nucleotide polymorphism (SNP) in the TOX3/LOC643714 region was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry and has been replicated in other populations of European ancestry.
|
20406955 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The most strongly associated SNP was in intron 2 of the FGFR2 gene that is amplified and overexpressed in 5-10% of BC. rs3803662 of TNRC9 gene has been shown to be the SNP with the strongest association with BC, in particular, this polymorphism seems to be correlated with bone metastases and estrogen receptor positivity.
|
21996731 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
|
23001122 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
|
23001122 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
TOX3-rs3803662, may confer some degrees of risk of breast cancer in Iranian population.
|
30515698 |
2019 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A case‑control study (90‑100 cases; 90‑100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women.
|
27572905 |
2016 |