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rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T genotype of MTHFR is associated with CVD in ESRD and may be a more meaningful marker than tHcy for abnormal homocysteine metabolism in ESRD.
|
11532106 |
2001 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence of methylenetetrahydrofolate gene (MTHFR) C677T polymorphism among chronic hemodialysis patients and its association with cardiovascular disease: a cross-sectional analysis.
|
19466593 |
2009 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism in the MTHFR gene (677C --> T) results in reduced enzymatic activity, and is associated with an increased risk for neural tube defects and cardiovascular disease.
|
19609317 |
2009 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease.
|
22782530 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this review we have focused on the correlations between plasma homocysteine levels, the incidence of cardiovascular disease and the cytosine-to-thymidine substitution at nucleotide 677 (C677T) of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, coding for a key enzyme in methionine-homocysteine metabolism.
|
14728017 |
2001 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma total homocysteine concentrations were highest in the subgroup of men with both polymorphisms, MTHFR 677C-->T TT and cSHMT 1420C-->T TT, consistent with a higher risk of CVD in this subgroup.
|
16046727 |
2005 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thrombophilic profile (factor V G1691A (Leiden), factor V H1299R (R2), prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIII V34L, β-fibrinogen-455 G-A and plasminogen activator inhibitor (PAI)-1 4G/5G) was evaluated using the cardiovascular diseases (CVD) StripAssay based on DNA isolation, PCR and reverse hybridisation.
|
31300468 |
2019 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations.
|
9974399 |
1999 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this large-scale prospective study, the association of homocysteine with CVD was markedly attenuated after adjusting for risk factors and was not modified by MTHFR 677C>T or intake of folate or B-vitamins.
|
17332146 |
2007 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease.
|
15837084 |
2005 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated total homocysteine (tHcy) concentrations and relations between tHcy and folate, cobalamin (Cbl), genetic polymorphisms (MTHFR 677C > T, MTHFR 1298A > C, MTHFR 1793G > A), blood pressure (BP), body mass index (BMI), cholesterol, triglycerides, sports activities, family and individual history of cardiovascular disease (CVD) and lifestyle issues in 264 healthy children and adolescents (2-17 y).
|
17065574 |
2006 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Particular emphasis has been given to the role of two common polymorphisms (MTHFR 677C-->T, 1298A-->C) in cardiovascular disease, cerebrovascular disease, venous thrombosis, longevity, neural tube defects, pregnancy/preeclampsia, diabetes, cancer, psychiatry, renal failure and renal replacement therapy.
|
10720211 |
2000 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
|
19952781 |
2010 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate.
|
24458267 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In cardiovascular diseases, the MTHFR C677T mutation: 1) is associated with plasma Hcy levels; 2) is an independent risk factor for cardiovascular diseases, 3) is associated with plasma BNP levels, and 4) plasma Hcy levels are positively correlated with plasma BNP levels.
|
16958597 |
2006 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Epidemiological studies, which provide a separate line of evidence to link this gene with blood pressure, show that the 677C→T polymorphism in MTHFR increases the risk of hypertension by 24-87% and CVD by up to 40%, albeit with a large geographical variation in the extent of excess disease risk suggestive of a gene-environment interaction.
|
27720779 |
2017 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A point mutation (C677T) in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved in homocysteine remethylation, has been reported to render the enzyme thermolabile and less active and has been associated with elevated tHcy in homozygous carriers (+/+ genotype) as well as with increased risk of premature cardiovascular disease.
|
8873653 |
1996 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a cross-sectional analysis of demographics, the diet, tHcy level, presence of the C677T mutation in the methylenetetrahydrofolate reductase gene (a common genetic cause of elevated tHcy) in children, and the prevalence of parental CVD. tHcy increased after puberty and was inversely related to parental educational level.
|
9323065 |
1997 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Elevated homocysteine is an independent risk factor for cardiovascular disease and has been associated with a common C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene.
|
10329022 |
1999 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease.
|
15494775 |
2004 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype.
|
16340945 |
2006 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutant alleles with the 677C-->T and 1298A-->C polymorphisms of the MTHFR gene, and consequent lower methylentetrahydrofolate reductase enzyme activity, have been related to higher plasma homocysteine levels, which are associated with cardiovascular diseases.
|
12356947 |
2002 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genes functioning in folate-mediated 1-carbon metabolism are hypothesized to play a role in cardiovascular disease (CVD) risk beyond the current narrow focus on the MTHFR 677 C→T (rs1801133) polymorphism.
|
22649255 |
2012 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.
|
25050994 |
2014 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
|
18622257 |
2008 |