|
rs1344706
|
|
Schizophrenia
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
|
18677311 |
2008 |
|
rs1344706
|
|
Schizophrenia
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
|
18677311 |
2008 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706).
|
19407193 |
2009 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia.
|
19844207 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P=2.5 × 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P=4.1 × 10(-13), OR 1.11, 95% confidence interval 1.07-1.14).
|
20368704 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this 2-stage study, we tested for an association between ZNF804A rs1344706 and cognitive functions known to be impaired in schizophrenia (IQ, episodic memory, working memory, and attention) in an Irish discovery sample.
|
20603450 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The only in vivo endophenotype study of the SZ-associated SNP (rs1344706) pointed towards effects on brain functional connectivity.
|
20664580 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus.
|
20688871 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia.© 2010 Wiley-Liss, Inc.
|
20957649 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Particularly rs1344706, initially surpassing the genome-wide significance level in an extended phenotype of schizophrenia and affective disorder, produced consistently negative results.
|
21302348 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia.
|
21349497 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses.
|
21457757 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs1344706 was not associated with schizophrenia in either of the two Han Chinese groups, and this result was confirmed by meta-analyses in five Han Chinese samples.
|
21890790 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients homozygous for the ZNF804A risk allele for schizophrenia (rs1344706 AA) showed poorer improvement of positive symptoms (7.35 ± 0.46) compared to patients with a protective allele (9.41 ± 0.71, P = 0.022).
|
21892778 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of rs1344706 with WM changes in schizophrenia patients and healthy controls was analyzed using a full-factorial 2×2 analysis of variance.
|
21911029 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using this method, we were able to replicate an association between ZNF804A rs1344706 variant and schizophrenia in a Turkish population.
|
21988329 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, we performed a four-SNP haplotype analysis which included the SNPs from the three-SNP haplotype analysis and rs1344706 (global P = 0.0005), and found that haplotype GCCG was associated with schizophrenia (P = 0.003).
|
21993378 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies identified the single nucleotide polymorphism rs1344706 in ZNF804A as a common risk-variant for schizophrenia and bipolar disorder.
|
22042765 |
2013 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Based on extant data in healthy controls (HC), we hypothesized that ZNF804A risk variant rs1344706 is associated with lower fractional anisotropy (FA) in brain regions within cortico-limbic circuits, namely frontal, parietal, medial temporal lobes, and cingulate gyri in SCZ.
|
22328493 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Together, these results indicated that IQ may modulate the role of rs1344706 in the etiology of both schizophrenia and its cognitive impairments, and pointed to the necessity of considering general cognitive function as indexed by IQ in the future studies of genetic bases of schizophrenia.
|
22373944 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in ZNF804a reached genome-wide statistical significance for association with a combined diagnosis of schizophrenia (SZ) and bipolar disorder.
|
22384243 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.
|
22425527 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693).
|
22775511 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This finding might be consistent with a previously reported ZNF804A association in schizophrenia, in which patients carrying the schizophrenia-risk allele at rs1344706 showed a better performance in two memory tests.
|
22781169 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.
|
22871346 |
2012 |