|
rs1344706
|
|
Schizophrenia
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
|
18677311 |
2008 |
|
rs1344706
|
|
Schizophrenia
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
|
18677311 |
2008 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706).
|
19407193 |
2009 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study replicates the original reported association of ZNF804A with schizophrenia and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for schizophrenia.
|
19844207 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus.
|
20688871 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia.© 2010 Wiley-Liss, Inc.
|
20957649 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this 2-stage study, we tested for an association between ZNF804A rs1344706 and cognitive functions known to be impaired in schizophrenia (IQ, episodic memory, working memory, and attention) in an Irish discovery sample.
|
20603450 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The only in vivo endophenotype study of the SZ-associated SNP (rs1344706) pointed towards effects on brain functional connectivity.
|
20664580 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Particularly rs1344706, initially surpassing the genome-wide significance level in an extended phenotype of schizophrenia and affective disorder, produced consistently negative results.
|
21302348 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The meta-analysis provided evidence for association between rs1344706 that surpasses widely accepted benchmarks of significance by several orders of magnitude for both schizophrenia (P=2.5 × 10(-11), odds ratio (OR) 1.10, 95% confidence interval 1.07-1.14) and schizophrenia and bipolar disorder combined (P=4.1 × 10(-13), OR 1.11, 95% confidence interval 1.07-1.14).
|
20368704 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs1344706 was not associated with schizophrenia in either of the two Han Chinese groups, and this result was confirmed by meta-analyses in five Han Chinese samples.
|
21890790 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses.
|
21457757 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia.
|
21349497 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, we performed a four-SNP haplotype analysis which included the SNPs from the three-SNP haplotype analysis and rs1344706 (global P = 0.0005), and found that haplotype GCCG was associated with schizophrenia (P = 0.003).
|
21993378 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
OBJECTIVE To evaluate associations of rs1344706</span> with brain structure and the core symptoms of schizophrenia.
|
22945618 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
This finding might be consistent with a previously reported ZNF804A association in schizophrenia, in which patients carrying the schizophrenia-risk allele at rs1344706 showed a better performance in two memory tests.
|
22781169 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we studied rs1344706 and schizophrenia susceptibility in multiple Asian case-control samples (10 Chinese and 2 Japanese samples; N = 21,062), and the meta-analyses indicated non-significant association of rs1344706 with schizophrenia (P = 0.26), suggesting the same SNP identified in European samples is not predisposing risk in Asians.
|
22887939 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, rs1344706 genotype had a significant effect on ZNF804A allelic expression in second-trimester fetal brain, with the schizophrenia risk (T) allele associated with reduced ZNF804A expression.
|
23212061 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.
|
22871346 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Based on extant data in healthy controls (HC), we hypothesized that ZNF804A risk variant rs1344706 is associated with lower fractional anisotropy (FA) in brain regions within cortico-limbic circuits, namely frontal, parietal, medial temporal lobes, and cingulate gyri in SCZ.
|
22328493 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Together, these results indicated that IQ may modulate the role of rs1344706 in the etiology of both schizophrenia and its cognitive impairments, and pointed to the necessity of considering general cognitive function as indexed by IQ in the future studies of genetic bases of schizophrenia.
|
22373944 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We tested the effect of rs1344706 genotype in 89 schizophrenia patients on 3 basic cognitive domains (working memory, processing speed and attention) shown to be severely impaired in schizophrenia.
|
22948380 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693).
|
22775511 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients homozygous for the ZNF804A risk allele for schizophrenia (rs1344706 AA) showed poorer improvement of positive symptoms (7.35 ± 0.46) compared to patients with a protective allele (9.41 ± 0.71, P = 0.022).
|
21892778 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using this method, we were able to replicate an association between ZNF804A rs1344706 variant and schizophrenia in a Turkish population.
|
21988329 |
2012 |