Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The <i>KCNJ11</i> SNP rs5210 was associated with T2DM, the <i>TCF7L2</i> SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the <i>TCF7L2</i> SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the <i>HNF4A</i> SNP rs1885088 was associated with LDL levels (P<0.05). 28352326

2017

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The heterozygous genotypes CT, GT and TC of the rs7903146 (T is risk for Type 2 diabetes), rs12255372 (T is risk for Type 2 diabetes) and rs7901695 (C is risk for Type 2 diabetes), respectively, as well as the homozygous genotypes TT, TT and CC of the rs7903146, rs12255372 and rs7901695, respectively, were strongly associated with gestational diabetes (P < 0.0001). 21672010

2011

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE T2D cases (n = 1140) and controls (n = 1915) from the Nurses' Health Study were genotyped for TCF7L2 (rs12255372). 19211816

2009

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466

2019

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D. 19602480

2009

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The GG genotype at rs12255372 favourably influences treatment success with sulfonylurea therapy in patients with type 2 diabetes (p⩽0.05). 27639123

2016

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide polymorphisms (SNPs) rs12255372 and rs7903146. 17130514

2006

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Furthermore, we identified a common protective haplotype defined by these four SNPs that was significantly associated with type 2 diabetes and age at diagnosis (P = 4.2 x 10(-5), relative risk [RR] 0.69; P = 6.7 x 10(-6), respectively) and a haplotype that confers diabetes risk that contains the rare alleles at SNPs rs10885390 and rs12255372 (P = 0.02, RR 1.64). 17259383

2007

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In addition, an association of two SNPs of the TCF7L2 gene with T2D was observed in both cities: rs7903146, (for Guerrero OR = 1.98 CI95% 1.02-3.89 and for Mexico OR = 1.94 CI95% 1.31-2.88) and rs12255372 (OR = 1.79 CI95% 1.08-2.97, OR = 1.78 CI95% 1.17-2.71 respectively). 21834909

2011

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE A total of 2,676 healthy European white middle-aged men from the prospective NPHSII (158 developed T2D over 15 years surveillance) were genotyped for two intronic SNPs [rs 7903146 (IVS3C>T) and rs12255372 (IVS4G>T)] which showed strong linkage disequilibrium (D' = 0.88, p<0.001; R(2)=0.76, p<0.001). 17665514

2006

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE PCOS carriers of the rs12255372 T (TCF7L2 Caucasian type 2 diabetes mellitus (T2D) locus) had no significant associated metabolic phenotypes. 22301903

2012

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Using a case-control design, we examined whether the reported variants [rs12255372 (T/G) and rs7903146 (T/C)] are associated with type 2 diabetes in SEARCH for Diabetes in Youth study participants. 21109996

2011

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE There was no evidence that rs12255372G/T and rs290487T/C polymorphisms increased T2DM risk (T vs. G, OR = 1.77, 95% CI = 0.88-3.56; C vs. T, OR = 1.08, 95% CI = 0.93-1.25). 23527206

2013

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE These results suggest that TCF7L2 variants rs7903146 rs12255372, and rs11196205 are significantly associated with angiographically diagnosed CAD, specifically in patients with T2DM. 21423583

2011

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604

2018

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In this study we examined the associations between SNPs rs7901695, rs7903146 and rs12255372 in the TCF7L2 gene and metabolic variables affecting type 2 diabetes in a population-based study of 706 unrelated individuals (47% men and 53% women; aged 35-74 years) from the province of Segovia in central Spain (Castille), including 180 individuals with type 2 diabetes. 18712344

2008

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We genotyped 309 German subjects at increased risk for type 2 diabetes for single nucleotide polymorphisms (SNPs) rs7903146, rs12255372, rs11196205, and rs7895340 in TCF7L2 and performed oral glucose tolerance tests before and after a 9-month lifestyle intervention. 20028944

2010

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation GWASDB A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. 17463248

2007

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2 gene were rare and were not associated with type 2 diabetes in a Chinese population, which may attribute to the low frequencies of these two SNPs. 17579206

2007

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. 18655717

2008

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. 17245407

2007

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-like 2 (TCF7L2) variants rs4506565, rs7903146, rs12243326, and rs12255372 with the susceptibility to PCOS. 24157263

2014

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In a prospective, nested, case-control study (n = 3,520) within the Nurses' Health Study (687 type 2 diabetic case and 1,051 control subjects) and the Health Professionals Follow-up Study (886 case and 896 control subjects), we examined the association of a common variant of the TCF7L2 gene (rs12255372 [T/G]) with type 2 diabetes risk among Caucasians. 16936216

2006

dbSNP: rs12255372
rs12255372
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we analysed two single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, in the transcription factor 7-like 2 gene (TCF7L2), which are associated with an increased risk of type 2 diabetes mellitus. 17618413

2007