|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR 677 C-->T mutation: a predictor of early-onset coronary artery disease risk.
|
11562338 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We were able to define a gene-nutrient interaction that shows a higher risk for CAD based on specific threshold folate levels required by different MTHFR C677T genotypes in a Korean population.
|
15935452 |
2006 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in Asian Indians from India was determined and the association of the mutant allele with coronary artery disease (CAD) was evaluated in a case-control study.
|
11940092 |
2002 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this generally well-nourished population, men with the +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increase in risk of coronary heart disease, even when intake of folate or other B vitamins is low.
|
9708460 |
1998 |
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rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease.
|
14604831 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease.
|
16274479 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to mild hyperhomocysteinemia and, therefore, to the incidence of coronary artery disease.
|
11319193 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The homozygous C677T genotype has previously been associated with coronary heart disease in Ireland.
|
9974399 |
1999 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that there is no association between the C677T mutation of the human MTHFR gene and the risk of CAD or VT among Chinese in Taiwan.
|
11096270 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalences of the C677T and A1298C genotypes did not differ significantly in 772 individuals with documented coronary artery disease (CAD), 137 individuals with deep-vein thrombosis (DVT), and 329 individuals without documented vascular disease.
|
11274015 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
|
18403793 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration.
|
20530057 |
2010 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that, in our population, the MTHFR C677T mutation is rather common, but it does not appear to be associated per se to CAD.
|
9596662 |
1998 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to a mild rise in plasma homocysteine levels and increase the incidence of coronary artery disease.
|
16489563 |
2006 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
|
22664498 |
2012 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although three common MTHFR polymorphisms (C677T, A1298C, T1317C) have been reported, only polymorphism C677T has been investigated intensively as a risk factor for coronary artery disease (CAD).
|
11257266 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No strong evidence exists to support an association of the MTHFR 677 C-->T polymorphism and coronary heart disease in Europe, North America, or Australia.
|
16216822 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
|
24218123 |
2013 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this work was to analyze the frequency of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in patients with CAD and its association with plasma homocysteine levels.
|
17505678 |
2007 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease.
|
27051002 |
2016 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the Chinese Han population, the TT genotype for the MTHFR C677T gene appeared to be associated with increased CAD risk.
|
22146089 |
2012 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
|
9806473 |
1998 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of the 677 C-->T and 1298 A-->C compound heterozygosity was 9.6% for the BD group and 12.3% for the CAD group.
|
14521457 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, while the C allele of the 677C/T MTHFR polymorphism is associated with type II diabetes mellitus in women, the T allele is associated with CAD only in normotensive subjects of Czech origin.
|
11386855 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We screened 284 patients who developed first symptoms of CAD at < or =65 years of age for fasting plasma homocysteine and the C677T mutation.
|
15950563 |
2005 |