Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. 17827400

2007

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363). 18162508

2008

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE IGF2BP2 variants rs4402960 and rs1470579 were not associated with type 2 diabetes in the present study (P = 0.632 and P = 0.896, respectively). 18430866

2008

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1. 18477659

2008

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE When combined, each additional risk allele from CDKAL1-rs9465871, CDKN2A/B-rs10811661, IGF2BP2-rs4402960, and SLC30A8-rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)). 18633108

2008

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634). 19033397

2009

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The analyses showed that age (P < 0.0001), BMI (P < 0.0001), and six variants (IGF2BP2 rs4402960, P = 0.002; ADIPOQ+276 G>T, P = 0.004; UCP2Ala55Val, P = 0.01; CDKN2AI2B rs3731201, P = 0.02; rs495490, P = 0.02, and rsl 0811661, P = 0.03) were significantly associated with the risk of IFG/IGT/T2DM. 20384434

2010

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. 20509872

2010

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The IGF2BP2 rs1470579 and rs4402960 polymorphisms may be associated with the development of T2DM, and these polymorphisms may affect the therapeutic efficacy of repaglinide in Chinese T2DM patients. 20523342

2010

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE We replicated an association between rs4402960 and T2D status, and reported significant associations with anthropometric traits, fasting insulin, HOMA-IR and HOMA-%B. 20627640

2010

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Our meta-analysis suggested that IGF2BP2 rs4402960 polymorphism conferred elevated risk of T2DM, especially in European, East Asian and South Asian populations. 21839790

2011

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE To investigate this inconsistency, we performed a meta-analysis of 35 studies involving a total of 175,965 subjects for two wildly studied polymorphisms (rs4402960 and rs1470579) of the IFG2BP2 to evaluate the effect of IFG2BP2 on genetic susceptibility for T2D. 22015911

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that rs4402960 polymorphism in IGF2BP2 is associated with elevated T2D risk, but these associations vary in different ethnic populations. 22032244

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE We validate that IGF2BP2 susceptibility variants rs4402960 and rs1470579 associate with T2DM in Lebanese Arabs. 22245690

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The risk associated with the presence of T2D was modified both by IGF2BP2_rs4402960 and PPARγ_rs1801282 SNP (P(interaction) = 0.04 and 0.04, respectively). 22419714

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11. 22569928

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The present study has replicated the association of IGF2BP2 rs4402960 with T2D in the Czech population and provided data suggesting that IGF2BP2 may have genetic interaction with IGF2 with a protective effect against DN in male patients with T1D. 22770937

2013

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). 22923468

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The association of Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) common variants (rs4402960 and rs1470579) with type 2 diabetes (T2D) has been performed in different populations. 23029108

2012

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Patients with schizophrenia have an increased prevalence of type 2 diabetes mellitus, and type 2 diabetes mellitus has shown an association with the rs4402960 gene polymorphism in the insulin-like growth factor II messenger RNA (mRNA)-binding protein 2 gene (IGF2BP2). 23656854

2013

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The meta-analysis also showed the association between T2DM and IGF2BP2 (rs1470579 OR of 1.15 (95% CI = 1.10-1.19), P < 0.0001 under an additive model and rs4402960 OR of 1.14 (95% CI = 1.10-1.18), P < 0.0001 under an additive model). 24229666

2013

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The present study confirms that the rs4402960 of IGF2BP2 gene is a strong candidate for Type 2 diabetes susceptibility and overweight/obesity risk in the Tunisian population. 24636221

2015

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples. 24736664

2014

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations. 24898818

2014

dbSNP: rs4402960
rs4402960
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05]. 24993573

2014