Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASDB IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations. 21228123

2011

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASDB Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. 20060832

2010

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASCAT IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations. 21228123

2011

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASCAT Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. 19749757

2009

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation GWASDB Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. 19684573

2009

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASCAT Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. 20060832

2010

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASCAT IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. 19749758

2009

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASDB IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. 19749758

2009

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
G 0.900 GeneticVariation GWASDB Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. 19749757

2009

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE With the screening for IL28B polymorphisms rs12980275, rs8099917 and rs12979860, which are associated with HCV chronicity and with reduced SVR rates, an important prognostic factor of the therapy of chronic hepatitis C can be easily diagnosed. 21149916

2010

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE The rs8099917 polymorphism should be the best predictor for the response to the PEG-IFN/RBV treatment among Japanese chronic hepatitis C patients. 21389156

2011

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE Genotype rs8099917 near the IL28B gene and amino acid substitution at position 70 in the core region of the hepatitis C virus are determinants of serum apolipoprotein B-100 concentration in chronic hepatitis C. 21879313

2012

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE These results demonstrate that the genotypes rs12979860 CC and rs8099917 TT were more frequently observed in Korean patients compared to other ethnicities, and suggest that the genetic characteristics of patients may be prognostic factor that predicts antiviral response to PEG-IFN therapy for chronic hepatitis C. 21907615

2011

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE We genotyped chronic hepatitis C (CHC) genotype 1 patients with PegIFN/R treatment-induced clearance (n = 417) and treatment failure (n = 493), and 234 individuals with spontaneous clearance, for HLA-C C1 versus C2, presence of inhibitory and activating KIR genes, and two IL28B SNPs, rs8099917 and rs12979860. 21931540

2011

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in IL28B and serum levels of interferon γ inducible protein 10 (IP-10) predict outcomes of antiviral therapy in patients with chronic hepatitis C. We associated IL28B SNPs rs12979860 and rs8099917, along with serum levels of IP-10, with outcomes of patients with acute hepatitis C (AHC). 22192885

2012

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE Patients with genotype 1b chronic hepatitis C (n = 446) treated with peg-interferon alpha and ribavirin (RBV) for 48 weeks were genotyped for the ITPA (rs1127354) and IL28B (rs8099917) genes. 23297176

2013

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917). 25130512

2014

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE This study assessed frequency of the IL-28 polymorphism (rs8099917) in 50 patients (39 men and 11 women ) with chronic hepatitis C using ZNA probe real time PCR new method . 25773845

2015

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE The three IL28B gene polymorphisms (CC genotype of rs12979860, TT genotype of rs8099917, and AA genotype of rs12980275) were associated with the SVR (p=0.029, p=0.016, and p=0.028, respectively) in the study patients with chronic hepatitis C treated with the combination therapy of PEGIFN α and RBV. 26614853

2015

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE Impact of IFNL4 rs12979860 and rs8099917 polymorphisms on response to Peg-Interferon-α and Ribavirin in patients with congenital bleeding disorder and chronic hepatitis C. 27735085

2017

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C. 28703131

2017

dbSNP: rs8099917
rs8099917
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic
0.900 GeneticVariation BEFREE The interleukin 28B gene polymorphism, rs8099917, in patients with chronic hepatitis C and response to the treatment with pegylated interferon and ribavirin. 30988680

2019

dbSNP: rs744373
rs744373
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841

2011

dbSNP: rs744373
rs744373
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation GWASDB Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. 21460840

2011

dbSNP: rs744373
rs744373
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation GWASDB The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. 21627779

2011