|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
1.000 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR.
|
30319545 |
2018 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A case-control study was performed in Han Chinese subjects with normal control (n=152) and T2DM (n=227), we genotyped rs7903146 and rs11196218 at TCF7L2, rs13266634 at SLC30A8, rs3811951 at PCSK1 and rs2021785 at PCSK2.
|
21437630 |
2012 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes.
|
30710592 |
2019 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes.
|
19542200 |
2009 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A significant association for SNP rs13266634 was observed between patients with type 2 diabetes and NGT controls (P = 0.016).
|
18628523 |
2008 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A significant association with type 2 diabetes was not observed for rs13266634.
|
17971426 |
2008 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A specific genetic variant, rs13266634 (c.973C>T; p.ARG325TRP) in zinc transporter SLC30A8/ZnT8, is associated with protection against Type-2 Diabetes, suggesting it may be actionable for predicting and preventing POHG.
|
31220282 |
2019 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044).
|
30142362 |
2018 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
|
26832344 |
2016 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1).
|
22923468 |
2012 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASCAT |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASDB |
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|
19401414 |
2009 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation
|
BEFREE |
Gene-environment interaction analysis showed a significant interaction between rs13266634</span> in SLC30A8 gene and age on T2DM risk (P<0.0001).
|
24736664 |
2014 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASCAT |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
rs13266634
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |