|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
|
19335934 |
2009 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
|
19153574 |
2009 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction).
|
21880305 |
2011 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission.
|
27409526 |
2017 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect.
|
29102837 |
2018 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
|
21692988 |
2011 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF:rs6265 Met-allele was overrepresented in depression for women with problems during their childhood.
|
20226536 |
2010 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
|
26462036 |
2015 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
|
24433458 |
2014 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
|
17222482 |
2008 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
|
25648279 |
2015 |
|
rs6265
|
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression.
|
19885623 |
2009 |