|
rs1013151
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
|
rs1029153
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, in this study we found that the favorable CXCL12 rs1029153 T allele seems to be related so as to achieve an SVR in HIV/HCV-coinfected patients on pegIFN-α/ribavirin therapy.
|
26499461 |
2016 |
|
rs1034713634
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
HCV pseudoparticle assays in Huh7.5 cells showed that HVR1 deletion decreased entry by 20- to 100-fold for H77, J6, and S52; N476D/S733F restored entry for H77(ΔHVR1), while A369V further impaired S52(ΔHVR1) entry.
|
24257605 |
2014 |
|
rs1042034
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
An APOB SNP, rs1042034, is closely associated with HCV infection through lipid metabolism alteration.
|
29382324 |
2018 |
|
rs1042522
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims at investigating the impact of P53 72 Arg/Pro and APO-1 -670 A/G polymorphisms on HCV genotype 4a susceptibility.
|
25108128 |
2014 |
|
rs1049606
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
These included novel SNPs for hepatocarcinogenesis with HCV CCND2 rs1049606, RAD23B rs1805329, CEP164 rs573455, and GRP78rs430397 in addition to the known SNPs MDM2 rs2279744 and ALDH2 rs671.
|
22004425 |
2012 |
|
rs1049807
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the association of CCL3 (rs1063340) and CCL4 (rs1049807) polymorphisms with hepatitis C virus (HCV) clearance and sustained virologic response (SVR).
|
29705123 |
2018 |
|
rs1051792
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that KIR2DL2-HLA-C1 and rs1051792 may represent molecular biomarkers to identify early onset HCV-related HCC.
|
29731972 |
2018 |
|
rs1052020291
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The NS2/C113S mutation also impaired infectious-HCV</span> assembly, DRM localization of NS2 and E2, and colocalization of NS2 with Core and endoplasmic reticulum lipid raft-associated protein 2 (Erlin-2).
|
31597774 |
2019 |
|
rs1052133
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
For OGG1 (Ser326Cys), GG (Cys/Cys) genotype and G-allele were increased significantly in chronic HCV and HCC patients compared to the controls (<i>P</i><0.05).
|
31354343 |
2019 |
|
rs1063340
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the association of CCL3 (rs1063340) and CCL4 (rs1049807) polymorphisms with hepatitis C virus (HCV) clearance and sustained virologic response (SVR).
|
29705123 |
2018 |
|
rs1063478
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The interaction analysis showed that experience of plasma donation interacted with the combined effects of rs1063478 and rs2284191 for HCV susceptibility, and the experience of whole blood donation interacted with the association of rs7383287 with HCV clearance.
|
25528575 |
2014 |
|
rs1063499
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination.
|
29966690 |
2018 |
|
rs10735810
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Impact of FokI (rs10735810) and BsmI (rs1544410) on Treatment of Chronic HCV Patients With Genotype 4.
|
27087054 |
2016 |
|
rs10766197
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs10814325
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
RECK Gene Promoter rs10814325 Polymorphism in Egyptian Patients with Hepatocellular Carcinoma on Top of Chronic Hepatitis C Viral Infection.
|
27268601 |
2016 |
|
rs10877012
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the CYP27B1-1260 promoter polymorphism rs10877012 had substantial impact on 1,25-dihydroxyvitamin D serum levels (72, 61, and 60 pmol/ml for rs10877012 AA, AC, and CC, respectively, p=0.04) and on SVR rates in HCV genotype 1, 2, and 3 infected patients (77% and 65% versus 42% for rs10877012 AA, AC, and CC, respectively, p=0.02).
|
21145801 |
2011 |
|
rs10945859
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among these SNPs, CT genotype of rs10945859 was found to have a significant association towards the clinical progression of chronic HCV infection to cirrhosis alone (OR = 1.850; 95% C. I.
|
27740515 |
2017 |
|
rs111200466
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs111511318
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006).
|
23964107 |
2014 |
|
rs11209026
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants of IL23R gene were investigated for association with many diseases like chronic inflammatory disorders, RA, inflammatory bowel diseases and the susceptibility to the development of gastric cancer but no data are available concerning the association of IL23R gene (rs11209026) polymorphism with HCC development in HCV patients.
|
25666505 |
2015 |
|
rs11249006
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis showed that IL28RA rs10903035-rs11249006 haplotype GG played a protective effect for HCV infection (OR=0.21, 95%CI=0.13-0.36, P<0.001; OR=0.20, 95%CI=0.12-0.34, P<0.001).
|
21742059 |
2011 |
|
rs1126579
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings highlight that variant CXCR2 rs</span>1126579 genotypes are associated with HCV</span> clearance within the Chinese population.
|
29948377 |
2018 |
|
rs1128503
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two variants exhibited a serology-specific effect: <i>ABCB1</i> rs1128503 (OR = 4.18, 95%CI: 1.55-11.29, <i>P</i> = 0.0048) showed an effect in the HBV-positive subgroup; and <i>ERCC1</i> rs3212986 (OR = 0.33, 95%CI: 0.18-0.60, <i>P</i> = 0.0003) showed an effect in the HCV-positive subgroup.
|
29085212 |
2017 |
|
rs1130409
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine the possible association between polymorphisms of DNA repair genes, including XRCC1 Arg194Tryp, Arg280His, and Arg399Glu, APE1 Asp148Glu, and NEIL2 Arg257Leu, and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).
|
29935355 |
2018 |