|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
CONCLUSIONS; The BRAF V600E mutation was present in all patients with HCL who were evaluated.
|
21663470 |
2011 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL).
|
21910720 |
2011 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
CONCLUSIONS; The BRAF V600E mutation was present in all patients with HCL who were evaluated.
|
21663470 |
2011 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL).
|
21910720 |
2011 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia.
|
22531170 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hairy cell leukemia has been shown to be strongly associated with the BRAF V600E mutation.
|
22133769 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the BRAF V600E mutation is present in all patients with HCL and that, in combination with clinical and morphologic features, represents a reliable molecular marker for this condition.
|
22072557 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A high degree of correlation was noted between the presence of BRAF V600E and established diagnostic criteria in 26/27 patients with HCL/HCL variant.
|
22313586 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation.
|
22210875 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BRAF-V600E was detected at different time points during the disease course, even after therapy, pointing to its pivotal role in HCL pathogenesis and maintenance of the leukemic clone.
|
22028477 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, in conjunction with prior data, our results suggest incorporation of BRAF V600E mutation analysis in the diagnostic workup of HCL cases.
|
22246856 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the BRAF V600E mutation was uniformly identified in one HCL series, which may provide insights into the pathogenic mechanisms.
|
22212971 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, SkE resensitized the PLX-4032-resistant 451Lu melanoma cell line (451Lu-R) and was more efficient than U0126, a MEK inhibitor, and PLX-4032 (PLX) at inducing the apoptosis of two hairy cell leukemia (HCL) patient samples carrying the B-Raf-V600E mutation.
|
23518796 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas.
|
23161722 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, our pyrosequencing-based assay provides a convenient, rapid, sensitive, and quantitative tool for the detection of BRAF p.V600E mutations in HCL for clinical diagnostic testing.
|
22706871 |
2012 |
|
rs121913377
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diagnostically, the BRAF(V600E) mutation is a powerful molecular marker for papillary thyroid carcinoma and, quite possibly, hairy cell leukemia as well.
|
22369373 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, in conjunction with prior data, our results suggest incorporation of BRAF V600E mutation analysis in the diagnostic workup of HCL cases.
|
22246856 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Importantly, SkE resensitized the PLX-4032-resistant 451Lu melanoma cell line (451Lu-R) and was more efficient than U0126, a MEK inhibitor, and PLX-4032 (PLX) at inducing the apoptosis of two hairy cell leukemia (HCL) patient samples carrying the B-Raf-V600E mutation.
|
23518796 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the BRAF V600E mutation is present in all patients with HCL and that, in combination with clinical and morphologic features, represents a reliable molecular marker for this condition.
|
22072557 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia.
|
22531170 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diagnostically, the BRAF(V600E) mutation is a powerful molecular marker for papillary thyroid carcinoma and, quite possibly, hairy cell leukemia as well.
|
22369373 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation.
|
22210875 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A high degree of correlation was noted between the presence of BRAF V600E and established diagnostic criteria in 26/27 patients with HCL/HCL variant.
|
22313586 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, our pyrosequencing-based assay provides a convenient, rapid, sensitive, and quantitative tool for the detection of BRAF p.V600E mutations in HCL for clinical diagnostic testing.
|
22706871 |
2012 |
|
rs113488022
|
|
Hairy Cell Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BRAF-V600E was detected at different time points during the disease course, even after therapy, pointing to its pivotal role in HCL pathogenesis and maintenance of the leukemic clone.
|
22028477 |
2012 |