|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The disease-associated PTPN22-R620W variant protein is likely involved in multiple stages of the pathogenesis of autoimmunity.
|
24364806 |
2014 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common polymorphism (C1858T) in the gene that encodes the protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with altered T-cell responses and increased susceptibility to rheumatoid arthritis (RA) and other autoimmune diseases.
|
25040563 |
2014 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.
|
23359562 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
PTPN22 1858C>T gene polymorphism has been associated with several autoimmune disorders including alopecia areata.
|
23570882 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
Previous studies identified the functional polymorphism 1858C/T in the gene PTPN22 in association with several autoimmune diseases and with resistance to tuberculosis (TB).
|
23499775 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The 1858T allele of protein tyrosine phosphatase nonreceptor type 22 (PTPN22; R620W) exhibits one of the strongest and most consistent associations with sporadic autoimmune disease.
|
22857794 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in Caucasians.
|
23333624 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this family, the C1858T variant might confer a high risk of autoimmunity.
|
22809281 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
We highlight the pathogenic significance of the C1858T PTPN22 polymorphism in human autoimmunity with special reference to Type 1 diabetes.
|
23261816 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two independent functional missense single nucleotide polymorphisms (SNPs) located within the PTPN22 gene (R263Q and R620W) have been associated with different autoimmune disorders.
|
23559857 |
2013 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
We set out to analyze the role of two major non-HLA gene polymorphisms associated with type 1 diabetes (T1D), PTPN22 1858C/T and insulin gene INS-23 A/T in progression to clinical T1D after the appearance of β-cell autoimmunity.
|
22357962 |
2012 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
C1858T single nucleotide polymorphism in PTPN22 encoding the R620W allele variant of Lyp-PTPN22 (a protein phosphatase negatively regulating T-cell activation) has been associated with autoimmunity.
|
22704547 |
2012 |
|
rs2476601
|
|
Autoimmune Diseases
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis revealed a clear distinction between the two groups of diseases with regard to their targeted tissues: most autoimmune diseases showing an insignificant association with PTPN22 C1858T manifest in skin, the gastrointestinal tract or in immune privileged sites.
|
23076337 |
2012 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The functional R620W (C1858T) polymorphism of the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, a member of the PTPs that negatively regulate T-cell activation, has been recently associated with susceptibility to various autoimmune diseases.
|
21543514 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PTPN22 rs2476601 genetic variant has been associated with rheumatoid arthritis (RA) and other autoimmune diseases.
|
21965649 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
An elevated PTPN22 1858C/T genotype frequency has been correlated with several autoimmune disorders which have T-cell and humoral components.
|
21585555 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results indicate that the PTPN22 gene polymorphism independent of the SNP rs2476601 might be a supplementary risk factor to AITD, but not in T1D in Koreans, contradicting a major contributory influence of the PTPN22 gene in explaining common mechanism underlying multiple autoimmune diseases.
|
22069277 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
In concordance with a previous data establishing PTPN22 1858 C/T SNP association with several autoimmune diseases, our findings provide further evidence that the PTPN22 gene may play an important role in the susceptibility to some autoimmune diseases.
|
21467606 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
These data strengthen evidence that the R620W mutation is a common risk factor in autoimmune diseases.
|
21131644 |
2011 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess whether the functional R620W polymorphism of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene encoding the lymphoid-specific tyrosine phosphatase, which is known to be associated with various autoimmune diseases, also confers increased risk for PS in the genetic homogeneous population of Crete.
|
20039785 |
2010 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
No association was found between C1858T polymorphism and diabetes-related autoimmunity (p = 0.173) or thyroid autoimmune disease (p = 0.321), respectively.
|
20438787 |
2010 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
Endometriosis has been suggested to be an autoimmune disease and recently, an allelic variation of the PTPN22 (C1858T) gene was revealed to be associated with the development of autoimmunity.
|
20070289 |
2010 |
|
rs2476601
|
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The data suggest that in Brazilian patients with TS, the PTPN22 C1858T polymorphism may be an important genetic factor predisposing to autoimmune disease risk.
|
20696024 |
2010 |