|
rs4680
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) revealed, a 12.3% increased frequency of 5HT2C rs3813929 T-allele and an 11.6% increased frequency of COMT rs4680 GG-genotype in individuals with IGT or T2D (chi(2), p = 0.05 and p = 0.06, respectively).
|
19690620 |
2009 |
|
rs3818361
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs997509
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, subjects carrying the rs997509 rare allele had higher risk of MS (odds ratio 2.4, 95% confidence interval: 1.3-4.3) and IGT (odds ratio 4.7, 95% confidence interval: 1.9-11.4) than common allele homozygotes.
|
18940878 |
2009 |
|
rs1799883
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
rs1486559930
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Examination of the P322S/+ metabolic phenotype revealed late-onset glucose intolerance.
|
31439647 |
2019 |
|
rs2721068
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the German subjects at increased risk for type 2 diabetes, SNPs rs2721068 and rs17446614 were significantly (P = 0.0045 and P = 0.0018, respectively) and SNPs rs17446593 and rs2297627 were nominally (P = 0.0091 and P = 0.0387, respectively) associated with beta-cell dysfunction. rs2721068, rs17446614, and rs2297627 were also nominally associated with impaired glucose tolerance (P = 0.0264, P = 0.0162, and P = 0.0221, respectively).
|
19141580 |
2009 |
|
rs2297627
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the German subjects at increased risk for type 2 diabetes, SNPs rs2721068 and rs17446614 were significantly (P = 0.0045 and P = 0.0018, respectively) and SNPs rs17446593 and rs2297627 were nominally (P = 0.0091 and P = 0.0387, respectively) associated with beta-cell dysfunction. rs2721068, rs17446614, and rs2297627 were also nominally associated with impaired glucose tolerance (P = 0.0264, P = 0.0162, and P = 0.0221, respectively).
|
19141580 |
2009 |
|
rs17446614
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the German subjects at increased risk for type 2 diabetes, SNPs rs2721068 and rs17446614 were significantly (P = 0.0045 and P = 0.0018, respectively) and SNPs rs17446593 and rs2297627 were nominally (P = 0.0091 and P = 0.0387, respectively) associated with beta-cell dysfunction. rs2721068, rs17446614, and rs2297627 were also nominally associated with impaired glucose tolerance (P = 0.0264, P = 0.0162, and P = 0.0221, respectively).
|
19141580 |
2009 |
|
rs9939609
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the DPS, altogether 490 (BMI≥25kg/m(2)) subjects with impaired glucose tolerance were genotyped for rs9939609.
|
20400278 |
2011 |
|
rs760555162
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using physiological tests and a biophysics approach based on nuclear magnetic resonance (NMR), we unexpectedly found that SOD1(G93A) ALS mice suffered from severe glucose intolerance, which was counteracted by high intensity swimming but not moderate intensity running exercise.
|
29104532 |
2017 |
|
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation.
|
8879960 |
1996 |
|
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, the data do not support the suggested involvement of the Gly40Ser polymorphism in impaired glucose tolerance and the hypothesis of an association between NIDDM and the glucagon receptor gene in this population.
|
8690179 |
1995 |
|
rs1801483
|
|
Impaired glucose tolerance
|
|
0.030 |
GeneticVariation
|
BEFREE |
Absence of association between the Gly40-->Ser mutation in the human glucagon receptor and Japanese patients with non-insulin-dependent diabetes mellitus or impaired glucose tolerance.
|
8931690 |
1996 |
|
rs867232360
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
At follow-up of the TNDM patients with genetic alterations, 43% developed diabetes or impaired glucose tolerance in later life (one with 6q24 duplication and two with N48D and E227K mutations at KCNJ11 gene).
|
17490422 |
2007 |
|
rs773641005
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
(1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively).
|
11593593 |
1999 |
|
rs1799945
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes.
|
12148086 |
2002 |
|
rs1799945
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
C282Y/H63D compound heterozygous individuals who had glucose intolerance had more severe fibrosis compared with those without glucose intolerance (1.0+/-1.0 vs. 0.1+/-0.3, P=0.01).
|
16584391 |
2006 |
|
rs1800562
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele frequencies of C282Y and H63D did not differ between diabetic and control groups nor among subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and diabetes.
|
12148086 |
2002 |
|
rs1169288
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
rs3813929
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) revealed, a 12.3% increased frequency of 5HT2C rs3813929 T-allele and an 11.6% increased frequency of COMT rs4680 GG-genotype in individuals with IGT or T2D (chi(2), p = 0.05 and p = 0.06, respectively).
|
19690620 |
2009 |
|
rs4402960
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
The analyses showed that age (P < 0.0001), BMI (P < 0.0001), and six variants (IGF2BP2 rs4402960, P = 0.002; ADIPOQ+276 G>T, P = 0.004; UCP2Ala55Val, P = 0.01; CDKN2AI2B rs3731201, P = 0.02; rs495490, P = 0.02, and rsl 0811661, P = 0.03) were significantly associated with the risk of IFG/IGT/T2DM.
|
20384434 |
2010 |
|
rs4402960
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
rs1181860747
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gly1057Asp polymorphism was not associated with insulin resistance or impaired insulin secretion in Finnish subjects with normal glucose tolerance (n = 295) or impaired glucose tolerance (n = 38).
|
11473060 |
2001 |
|
rs1801278
|
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.
|
9589236 |
1998 |
|
rs1805097
|
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
These data indicate that IRS2 is an influential gene in severe obesity and glucose intolerance in this population, whereas gene-based haplotypes of IRS2 have revealed heterogeneity in the behaviour of the Gly1057Asp mutation in relation to insulin resistance.
|
12687350 |
2003 |