|
rs2231142
|
|
Diffuse Large B-Cell Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study demonstrates that the ABCG2 Q141K polymorphism may correlate with chemotherapy-induced diarrhea in patients with DLBCL who have received frontline R-CHOP chemotherapy, and this has implications for optimizing treatment with such agents.
|
19032367 |
2008 |
|
rs2231142
|
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCG2 Q141K polymorphism is associated with chemotherapy-induced diarrhea in patients with diffuse large B-cell lymphoma who received frontline rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone chemotherapy.
|
19032367 |
2008 |
|
rs2231142
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, this study prioritizes ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients.
|
19107936 |
2009 |
|
rs2231142
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, this study prioritizes ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients.
|
19107936 |
2009 |
|
rs2231142
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, this study prioritizes ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients.
|
19107936 |
2009 |
|
rs2231142
|
|
Hyperuricemia
|
|
0.800 |
GeneticVariation
|
BEFREE |
Associations of the rs2231142 variant with serum uric acid levels and prevalence of gout and hyperuricaemia were examined.
|
20421215 |
2010 |
|
rs199976573
|
|
Lung Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, Klf5 is not required for lung tumor formation in an inducible oncogenic K-Ras(G12D) mouse model of lung tumorigenesis, and non-small cell lung cancer patients expressing high levels of KLF5 (21/258) have a significantly better disease-specific survival than those with intermediate to no KLF5 expression.
|
20639455 |
2010 |
|
rs199976573
|
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that resveratrol inhibits pancreatic cancer stem cell characteristics in human and Kras(G12D) transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
|
21304978 |
2011 |
|
rs199976573
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that resveratrol inhibits pancreatic cancer stem cell characteristics in human and Kras(G12D) transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
|
21304978 |
2011 |
|
rs199976573
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Resveratrol inhibits the self-renewal capacity of pancreatic CSCs derived from human primary tumors and Kras(G12D) mice.
|
21304978 |
2011 |
|
rs1185675198
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans.
|
21655989 |
2011 |
|
rs1185675198
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans.
|
21655989 |
2011 |
|
rs6857600
|
|
B-Cell Lymphomas
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriers of the SNP rs6857600 minor allele in ABCG2 was associated with a decrease in risk of B-cell lymphoma (B-NHL) overall (p < 0.001).
|
21918980 |
2012 |
|
rs2231142
|
|
Chronic Lymphocytic Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, a decreased risk of chronic lymphocytic leukemia (CLL) was associated with the ABCG2 rs2231142 variant (p = 0.0004), which could be replicated in an independent population.
|
21918980 |
2012 |
|
rs2231142
|
|
Primary malignant neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the ABCG2 C421A polymorphism is a protective factor for developing cancer.
|
22937733 |
2012 |
|
rs2231142
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the ABCG2 C421A polymorphism is a protective factor for developing cancer.
|
22937733 |
2012 |
|
rs2231142
|
|
Myeloid Leukemia, Chronic
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results of the present study may indicate that the ABCG 421C>A genetic polymorphism influences the MMR of imatinib in patients with CML.
|
23117072 |
2013 |
|
rs2231142
|
|
Hyperuricemia
|
|
0.800 |
GeneticVariation
|
BEFREE |
The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4×10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6×10(-10)).
|
23238572 |
2013 |
|
rs2231142
|
|
Hyperuricemia
|
|
0.800 |
GeneticVariation
|
BEFREE |
Finally, we have demonstrated the utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout.
|
23493553 |
2013 |
|
rs4148149
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest ABCG2 htSNPs rs2725264 (overall group and taxane-platinum combination group) and rs4148149 (gemcitabine-platinum combination group) were associated with OS in unresectable NSCLC patients treated with first-line platinum-based chemotherapy.
|
23689644 |
2015 |
|
rs2725264
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest ABCG2 htSNPs r</span>s2725264 (overall group and taxane-platinum combination group) and rs4148149 (gemcitabine-platinum combination group) were associated with OS in unresectable NSCLC patients treated with first-line platinum-based chemotherapy.
|
23689644 |
2015 |
|
rs1305398818
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To study the possible mechanisms of S100P enhanced the chemosensitivity to oxaliplatin in gastric cancer cell lines.
|
23736016 |
2013 |
|
rs1305398818
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
To study the possible mechanisms of S100P enhanced the chemosensitivity to oxaliplatin in gastric cancer cell lines.
|
23736016 |
2013 |
|
rs1305398818
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The effect of the protein S100P on biological characteristics of cancer is not clear, especially in gastric cancer.
|
23736016 |
2013 |
|
rs1305398818
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The effect of the protein S100P on biological characteristics of cancer is not clear, especially in gastric cancer.
|
23736016 |
2013 |