|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that in the Japanese population, individuals harboring the G-allele of rs738409 were susceptible to NAFLD, and that rs738409 was associated with plasma levels of ALT, AST, and ferritin, and the histological fibrosis stage.
|
21176169 |
2010 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics.
|
23510779 |
2013 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
PNPLA3 variant rs738409 has been identified as important progression factor in patients with ALD and NAFLD, the most common liver diseases worldwide.
|
30362098 |
2019 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic.
|
24917523 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These closely resembled those between obese subjects with NAFLD but without PNPLA3(I148M) versus those with the I148M variant and NAFLD.
|
24009255 |
2014 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, PNPLA3 rs738409 may be more relevant to the progression of non-obese NAFLD when compared to obese NAFLD.
|
29609501 |
2018 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 300 Finnish subjects for the E167K (rs58542926) variant in TM6SF2 and for the I148M (rs738409) variant in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) in whom LFAT was measured using 1H-MRS and circulating lipids by UPLC-MS. We compared the plasma lipidome between E167K carriers (TM6SF2EK/KK) and non-carriers (TM6SF2EE), and between three groups of NAFLD: (i) carriers of the E167K but not of the I148M variant in PNPLA3 ('TM6SF2 NAFLD'), (ii) carriers of the I148M but not of the E167K variant ('PNPLA3 NAFLD'), and (iii) non-carriers of either risk allele ('Non-risk NAFLD').
|
25457209 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2.11-7.21; P = 3.6 x 10(-43)).
|
20648472 |
2010 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ADPN I148M polymorphism has been consistently reported to play a role in liver-associated diseases, such as alcoholic liver disease, chronic hepatitis C, and liver fat and fibrosis in nonalcoholic fatty liver disease.
|
26632699 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variation in both patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) influences severity of liver disease, and serum triglyceride concentrations in non-alcoholic fatty liver disease (NAFLD), but whether either genotype influences the responses to treatments is uncertain.
|
26272871 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
By summarizing the amount of evidence, this study provided unequivocal evidence of rs738409 as a strong modifier of the natural history of NAFLD in different populations around the world.
|
21381068 |
2011 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 variant is associated with adiponectin levels in patients with NAFLD and in healthy subjects, but in the presence of adiponectin resistance not in CHC patients.
|
22898488 |
2012 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
NAFLD association of PNPLA3 rs738409 was more pronounced among lean individuals (one-tailed p < 0.05) compared to the whole cohort sample.
|
30539516 |
2019 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A genetic variant of patatin-like phospholipase domain-containing 3 (PNPLA3-I14</span>8M) is the most prominent heritable factor associated with NAFLD.
|
29286303 |
2017 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the U.S. population, PNPLA3 I148M and higher NAFLD liver fat and fibrosis scores were associated with increased liver disease mortality.
|
31705824 |
2020 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 polymorphism is not only a factor significantly associated with the susceptibility of NAFLD, but also related to the susceptibility of aggressive diseases.
|
30762732 |
2019 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a sample of 230 overweight/obese children, 105 with NAFLD (hepatic fat fraction ≥5% by magnetic resonance imaging) and 125 without NAFLD, rs738409 in PNPLA3, rs58542926 in TM6SF2, rs1260326 in GCKR, and rs641738 in MBOAT7 were genotyped.
|
31505904 |
2019 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 C > G polymorphism is associated with the risk of progression to cirrhosis in NAFLD patients.
|
27150500 |
2016 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We determined the risk factors for HCC, including the PNPLA3 rs738409 polymorphism, in Japanese patients with biopsy-proven NAFLD.
|
27862719 |
2017 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, the G allele of PNPLA3 rs738409 and weight gain ≥10 kg after age 20 had a joint effect on the risk of NAFL</span>D in the normal weight (OR 12.00; 95% CI: 3.71-38.79; P = 3.3×10-5) and the overweight individuals (OR 13.40; 95% CI: 2.92-61.36; P = 0.0008).
|
26485523 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs738409 G allele was significantly associated with NAFLD (P < 0.001; OR 2.8 95%, CI 1.5-5.2), independent of age, sex, body mass index (BMI), and Homeostasis Model Assessment (HOMA) index.
|
19738004 |
2009 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Finally, we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148M variant in fibrogenesis, which, in turn, provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis.
|
25624712 |
2015 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease.
|
21878620 |
2011 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD).
|
27836992 |
2017 |
|
rs738409
|
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study reports an association between the PNPLA3-I148M polymorphism and insulin resistance and NAFLD in a normoglycaemic population.
|
21745282 |
2011 |