|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) is responsible, in the homozygous state, for decreased enzyme activity and mild hyperhomocysteinemia and is associated with increased risk for cardiovascular disease.
|
9327760 |
1997 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and hyperhomocysteinemia were more prevalent than other thrombophilias.
|
17688607 |
2007 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It suggests that MTHFR C677T mutation is associated with hyperhomocysteinemia in the ischemic CRVO in the Chinese population.
|
17719079 |
2008 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism and hyperhomocysteinemia have been associated with congenital malformations of the heart and neural tube defects.
|
17510921 |
2007 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298 polymorphisms (individually or in concert) and hyperhomocysteinemia represent important risk factors for IS.
|
23642756 |
2013 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 677C>T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is an important cause of mild hyperhomocysteinaemia.
|
14656017 |
2003 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the common (677C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with hyperhomocysteinemia, but there is uncertainty as to the association between this mutation and coronary artery disease (CAD).
|
10595952 |
1999 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
|
23285280 |
2012 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hyperhomocysteinemia in patients homozygotes for the C677T mutation may interfere with erection mechanisms and thus be responsible for ED.
|
19694922 |
2010 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants.
|
12015164 |
2002 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T heterozygous allele in the MTHFR gene was found to be associated with hyperhomocysteinemia in the patient and other family members.
|
22665972 |
2012 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While results from this study clearly demonstrate a strong association of hyperhomocysteinemia and homozygosity of the MTHFR C677T, but not FV-Leiden or PRT G20210A, mutations with confirmed CAD, they also suggest a potential role for factor V-Leiden in MTHFR C677T carriers.
|
15353918 |
2004 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism was not related to SVD and LVD, although the TT genotype was an important determinant of hyperhomocysteinemia.
|
25031284 |
2014 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggests that both C677T and A1298C MTHFR polymorphisms should be examined when assessing genetic risk factors of hyperhomocysteinemia in epilepsy.
|
15970629 |
2004 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which seems to be related to the homozygous condition for the MTHFR 677C-->T mutation.
|
11277368 |
2000 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of methylenetetrahydrofolate reductase (MTHFR) 677C>T gene polymorphism with hyperhomocysteinemia, renal failure, and cardiovascular events is controversial.
|
23534584 |
2013 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
He was found as having MTHFR C677T homozygote and plasminogen activator inhibitor-1 4G/5G heterozygote gene mutation with high homocysteine level of 22.90 µmol/L, and he was diagnosed as hyperhomocysteinemia.
|
31409160 |
2019 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
After multiple adjustment for other univariate predictors by Cox regression, including statin therapy (the most powerful predictor in uni-/multivariate analyses), high-sensitivity C Reactive Protein (hs-CRP) levels, and all known major genetic (MTHFR 677C-->T polymorphism) and non-genetic (B-group vitamin status and renal function) tHcy determinants, HHcy remained an independent prognostic factor for mortality (HRs: 5.02, 95% CIs 1.88 to 13.42, P = 0.001).
|
17183715 |
2006 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia.
|
20031640 |
2009 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that although the C677T/MTHFR mutation is a major cause of mild hyperhomocysteinemia, the mutation does not increase cardiovascular risk.
|
9843457 |
1998 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the incidence of methylene tetrahydrofolate reductase (MTHFR) gene 677C-->T polymorphism and plasma homocysteine (Hcy) levels in a group of subjects who underwent coronary angiography, in an attempt to establish a correlation between these parameters and the severity of coronary artery disease (CAD) and to investigate the correlation between hyperhomocysteinemia (HHcy) and the presence of 677C-->T polymorphism.
|
18074111 |
2008 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We calculated the prevalences of prothrombin G20210A, factor V G1691A (also associated with high risk for DVT) and homozygous methylenetetrahydrofolate reductase (MTHFR) C677T (associated with increased susceptibility to develop hyperhomocysteinemia) in 118 patients with a first episode of DVT and in 416 healthy controls.
|
10065893 |
1999 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events.
|
10780318 |
2000 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the 677 C-->T genotype is a strong factor for predisposition to hyperhomocysteinemia and recurrent risk of stroke that might also be prevented with folate supplementation.
|
10830195 |
2000 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation of the methylenetetrahydrofolate reductase gene, which may lead to hyperhomocysteinemia, is also considered a risk factor for VTE in some studies.
|
17401546 |
2007 |