Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. 30470734

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE rs7903146-T is associated with a decreased insulin concentration and increased risk of T2D with opposing effects of adjustment for adiposity. 29174029

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146 T allele in transcription factor 7 like 2 (<i>TCF7L2</i>) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. 29326107

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies. 29331016

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The meta-analysis suggested that rs7903146 was significantly associated with T2DM in Caucasian, East Asian, South Asian and other ethnicities. 29514658

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We performed a family study and determined if the T risk allele of the rs7903146 in the TCF7L2 gene increases the risk of type 2 diabetes based on real-time stable isotope measurements of insulin synthesis during an Oral Glucose Tolerance Test. 29631902

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The T2DM individuals carrying the rs7903146 T allele of the <i>TCF7L2</i> gene presented higher IR pattern in response to a mix-meal test, different of beta cell function at baseline assessed by C-peptide levels which was lower, and Homa-IR was lower when comparing with non-carriers. 29736187

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Five SNPs in KCNQ1 (rs2237892), CDK2A/2B (rs108116610, SLC30A8 (rs13266634), TCF7L2 (rs7903146) and MTNR1B (rs1387153) were found to be marginally associated with risk of developing T2D, with odds ratios ranging from 1.43 to 2.02 (p = 0.047 to 3.0 × 10-4) with adjustments for age, sex, and body mass index. 29871606

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE However, the additional presence of TCF7L2 rs7903146 risk alleles does not further aggravate the negative impact of a history of gestational diabetes on metabolic traits related to T2DM. 30419301

2018

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). 28254843

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE TCF7L2 variant rs7903146 is associated with increased risk for type 2 diabetes. 28183453

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. 28220878

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE SNP rs7903146 in the Wnt pathway's TCF7L2 gene is the variant most significantly associated with type 2 diabetes to date, with associations observed across diverse populations. 28253288

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Contrary to previous studies, the key T2D risk allele at TCF7L2 (rs7903146-T) had a significantly lower frequency in LADA cases, suggesting that this locus does not play a role in LADA etiology. 28438156

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146 variant in the <i>TCF7L2</i> gene increases the risk of IGT/T2D in obese adolescents by impairing β-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time. 28611053

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE After adjusting for age, gender, drinking, smoking and body mass index (BMI), the association of <i>TCF7L2</i> rs7903146C>T and rs290481 T>C polymorphisms with T2DM was determined. 29100364

2017

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502

2016

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes. 26914832

2016

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04). 27053251

2016

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE By replicating the analysis of association with T2D between case-controls from the Sigma Project, we determined that T2D was most highly associated with the rs7903146 risk allele and to a lesser extent with the other six variants. 27230431

2016

dbSNP: rs7903146
rs7903146
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D. 27310578

2016