|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies three novel loci for type 2 diabetes.
|
23945395 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC.
|
24435973 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASDB |
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
|
20818381 |
2010 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The authors then performed a large meta-analysis of 36 studies examining the association of type 2 diabetes mellitus (T2DM) with polymorphisms in the TCF7L2 gene in various ethnicities, containing rs7903146 C-to-T (IVS3C>T), rs7901695 T-to-C (IVS3T>C), a rs12255372 G-to-T (IVS4G>T), and rs11196205 G-to-C (IVS4G>C) polymorphisms and to evaluate the size of gene effect and the possible genetic mode of action.
|
19228405 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.900 |
GeneticVariation
|
GWASCAT |
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
|
30470734 |
2018 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.
|
19713311 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
|
23209189 |
2013 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Comparison between allele and genotype frequencies of these SNPs in patients and controls showed marginal association for rs7903146 and rs290487 with type 2 diabetes (p = 0.063, OR 1.982, 95% CI 1.128-3.485; p = 0.071, OR 1.237, 95% CI 0.983-1.557, respectively).
|
18493736 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, case-control studies demonstrated that a TCF7L2 (transcription factor 7-like 2 gene) noncoding variant (rs7903146 T at-risk allele) was strongly associated with an increased risk of type 2 diabetes.
|
17065361 |
2006 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The presence of the <i>TCF7L2</i> rs7903146 T allele in patients with T2DM was associated with increased secretion of insulin response to a mixed-meal test.
|
30700996 |
2019 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
|
23209189 |
2013 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population.
|
30776466 |
2019 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
In addition, rs7754840 (CDKAL1) was associated in the nonobese type 2 diabetic subgroup, and for rs7903146 (TCF7L2), association was observed for early-onset type 2 diabetes.
|
22923468 |
2012 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
|
17668382 |
2007 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The prediction of rs7903146 (C>T) is required in drug research and routine treatment, where the information would be helpful for clinicians to optimize therapy and adverse drug reactions and predict drug response in individuals at risk of T2D.
|
26604685 |
2015 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Elevated hepatic glucose production and reduced insulinotropic effect of incretin hormones contribute to an increased risk of type 2 diabetes in carriers of the rs7903146 risk T allele of TCF7L2.
|
19288077 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes.
|
26914832 |
2016 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The T2DM individuals carrying the rs7903146 T allele of the <i>TCF7L2</i> gene presented higher IR pattern in response to a mix-meal test, different of beta cell function at baseline assessed by C-peptide levels which was lower, and Homa-IR was lower when comparing with non-carriers.
|
29736187 |
2018 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g.
|
31123324 |
2019 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs7903146 at the transcription factor 7-like 2 (TCF7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome-wide association studies.
|
29331016 |
2018 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilian cohort of patients with known coronary heart disease.
|
19055834 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggest that the TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment.
|
31070566 |
2019 |
|
rs7903146
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D.
|
19602480 |
2009 |