rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent studies have also linked rs2736100 with a longer telomere length and lung cancer risk.
|
26554909 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer (P=4×10(-3) in the 1st stage association, P=4×10(-4) in the 2nd stage validation, and P=1×10(-5), odds ratio=1.24 in the combined population).
|
23368278 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In addition, the rs2736100 G allele, which we previously have shown to be associated with risk of lung cancer in this cohort, was significantly associated with longer telomere length in these same study subjects (P trend = 0.030).
|
23555636 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
|
24283584 |
2013 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
G |
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
|
23143601 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
rs2736100
|
|
Malignant neoplasm of lung
|
C |
0.800 |
GeneticVariation
|
GWASDB |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 1.31-1.56, P = 7.8 x 10(-16)).
|
20061363 |
2010 |
rs2736100
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
A statistically significant association between lung cancer risk and 5p15.33 genotypes was found: rs2736100 (odds ratio = 0.78, 95% confidence interval: 0.63-0.97; P = 0.02), rs4975616 (odds ratio = 0.69, 95% confidence interval: 0.55-0.85; P = 7.95 x 10(-4)), primarily for adenocarcinoma.
|
19955392 |
2010 |
rs401681
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
rs401681
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
rs401681
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
rs401681
|
|
Malignant neoplasm of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer.
|
29033187 |
2017 |