|
rs1051730
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Smoking behavior and COPD are mediators of the association between the single nucleotide polymorphism (SNP) rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |
|
rs1051730
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided).
|
20554942 |
2010 |
|
rs1051730
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk.
|
19247474 |
2009 |
|
rs1051730
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects.
|
18780872 |
2008 |
|
rs1051730
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
BEFREE |
We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose.
|
19010884 |
2008 |
|
rs1051730
|
|
Carcinoma of lung
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
rs121909071
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the College of American Pathologists/International Association for the study of lung cancer/association for molecular pathology guideline.
|
25311215 |
2014 |
|
rs121909071
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group.
|
24627688 |
2014 |
|
rs121909071
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Non-small cell lung cancer and precision medicine: a model for the incorporation of genomic features into clinical trial design.
|
24846033 |
2014 |
|
rs121909071
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.
|
23562183 |
2013 |
|
rs121909071
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group.
|
23667368 |
2013 |
|
rs121909071
|
|
Carcinoma of lung
|
T |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121913351
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the College of American Pathologists/International Association for the study of lung cancer/association for molecular pathology guideline.
|
25311215 |
2014 |
|
rs121913351
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group.
|
24627688 |
2014 |
|
rs121913351
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Non-small cell lung cancer and precision medicine: a model for the incorporation of genomic features into clinical trial design.
|
24846033 |
2014 |
|
rs121913351
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.
|
23562183 |
2013 |
|
rs121913351
|
|
Carcinoma of lung
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group.
|
23667368 |
2013 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.
|
23833300 |
2013 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.
|
21483012 |
2011 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
|
19238210 |
2009 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Genetic predictors of MEK dependence in non-small cell lung cancer.
|
19010912 |
2008 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
BRAF and RAS mutations in human lung cancer and melanoma.
|
12460918 |
2002 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Missense mutations of the BRAF gene in human lung adenocarcinoma.
|
12460919 |
2002 |
|
rs121913351
|
|
Carcinoma of lung
|
A |
0.800 |
CausalMutation
|
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |