|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activity and have been associated with reduced risk for a variety of cancers such as acute lymphocytic leukemia, lung and colorectal cancer.
|
18804702 |
2008 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA samples taken from patients with ALL and controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays to detect the MTHFR C677T and A1298C mutations.
|
17970089 |
2007 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, 677T allele was linked to a decrease risk of ALL [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.22-0.86], whereas the 1298A>C polymorphism presents an elevated risk factor [OR, 2.01; 95% CI, 1.01-3.99] in non-White children.
|
16182363 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association between the A1298C variant and susceptibility to both adult and childhood ALL was disclosed.
|
17035405 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2 or *3 and the risk of acute lymphoblastic leukemia (ALL).
|
17023046 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations found in these studies were significant with respect to gender bias; hence, it is possible that MTHFR C677T and A1298C can be good markers for ALL.
|
16923565 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We retrospectively evaluated the association of the MTHFR 677C>T and 1298A>C polymorphisms with pediatric ALL by genotyping a study sample of 443 ALL patients consecutively enrolled onto the German multicenter trial ALL-BFM 2000 and 379 healthy controls.
|
15921520 |
2005 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy.
|
15003888 |
2004 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
|
11736945 |
2001 |