|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.
|
23220171 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
|
22666430 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interdependence and roles of T cell-mediated immune responses and IL28B rs12979860 single-nucleotide polymorphism genotype as predictors of virological response to anti-HCV treatment in patients with chronic hepatitis C were evaluated using nonparametric tests.
|
28440692 |
2017 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype.
|
21647799 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005).
|
23358556 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917).
|
25130512 |
2014 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
To evaluate the effect of single nucleotide polymorphisms of interleukin (IL)-28B, rs12979860 on progression and treatment response in chronic hepatitis C.
|
23002361 |
2012 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients.
|
23440114 |
2013 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between IL28B rs12979860 genotype, the level of TNFα activation and the degree of IR in patients with chronic hepatitis C. One hundred and thirty-three nondiabetic genotype 1 HCV-infected patients with biopsy proven noncirrhotic hepatitis C were investigated for IR (using HOMA index), IL28B rs12979860 genotype and fasting circulating levels of soluble receptor 1 of TNFα (sTNFR1) and adipokines: leptin, adiponectin and IL-6.
|
25818002 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the screening for IL28B polymorphisms rs12980275, rs8099917 and rs12979860, which are associated with HCV chronicity and with reduced SVR rates, an important prognostic factor of the therapy of chronic hepatitis C can be easily diagnosed.
|
21149916 |
2010 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results demonstrate that the genotypes rs12979860 CC and rs8099917 TT were more frequently observed in Korean patients compared to other ethnicities, and suggest that the genetic characteristics of patients may be prognostic factor that predicts antiviral response to PEG-IFN therapy for chronic hepatitis C.
|
21907615 |
2011 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the single-nucleotide polymorphism (SNP) rs12979860 in the IL28B gene is a better predictor of sustained virological response to treatment of chronic hepatitis C (CHC) than other baseline factors, some CHC patients with the favorable C allele cannot achieve a sustained virological response when treated with peginterferon plus ribavirin.
|
25687192 |
2015 |
|
rs12979860
|
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions -P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing.
|
25872416 |
2015 |