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rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI).
|
19963114 |
2009 |
|
rs1052133
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis.
|
21695387 |
2011 |
|
rs1052133
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer.
|
22799296 |
2012 |
|
rs1052133
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma.
|
12164330 |
2002 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.
|
18977234 |
2008 |
|
rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1 Ser326Cys polymorphism and lung cancer risk.
|
22540013 |
2012 |
|
rs1052133
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |
|
rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Despite some limitations, this meta-analysis provides solid evidence that hOGG1 Ser326Cys polymorphism may contribute to lung cancer risk, particularly for Asian populations, never smokers, and more-cigarette takers.
|
24085357 |
2014 |
|
rs1052133
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a hospital-based, case-control study of 455 lung cancer cases and 443 cancer-free hospital controls, the SNPs of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their correlation with the risk of lung cancer in multivariate logistic regression models.
|
21722819 |
2011 |
|
rs1052133
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of all 13 studies showed that OGG1 rs1052133 polymorphism was significantly associated with the risk of colo</span>rectal cancer in Caucasian population (Cys versus Ser OR = 1.20, 95% CI = 1.03-1.39, P = 0.02; CysCys versus SerSer OR = 1.44, 95% CI = 1.04-2.00, P = 0.03; CysCys versus SerSer/SerCys OR = 1.39, 95% CI = 1.15-1.67, P = 0.0005).
|
23975367 |
2014 |
|
rs1052133
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
For example, there was a positive association between the OGG1 Ser326Cys variant and gastric and lung cancer, while the XRCC1 Arg399Gln variant was associated with reduced cancer risk.
|
23023028 |
2012 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly ~14-fold increased risk was associated with Val159Gly (p < 0.01), ~17-fold with Gly221Arg (p < 0.005), and ~18-fold with Ser326Cys (p < 0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p < 0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls.
|
26089588 |
2015 |
|
rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of tobacco exposure and the OGG1 Ser326Cys showed also no significant risk for lung cancer.
|
19161591 |
2009 |
|
rs1052133
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models.
|
24435978 |
2014 |
|
rs1052133
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our result could explain the association between hOGG1 Ser326Cys polymorphism and GC risk.
|
22294108 |
2012 |
|
rs1052133
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms and the susceptibility to colorectal carcinoma with or without oxidative stress were evaluated.
|
20649433 |
2010 |
|
rs1052133
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
We demonstrated a novel, significant correlation between the hOGG1 Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians.
|
22855704 |
2012 |
|
rs1052133
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), and APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their association with breast cancer risk using multivariate logistic regression models.
|
24606430 |
2014 |
|
rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a statistically significant interaction between the polymorphism and dietary intake of vegetables, with a 54% decrease in lung cancer risk per 50% increase in vegetable intake among homozygous Cys326Cys carriers and no decrease in risk among carriers of Ser326Ser or Ser326Cys.
|
17015267 |
2006 |
|
rs1052133
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Case-control studies of genetic polymorphisms in DNA repair enzymes suggest that the common variant Ser326Cys in OGG1 may be a risk factor for lung cancer, whereas a rare variant in OGG1 and germ line mutations in the corresponding mismatch repair gene MYH are risk factors for hereditary colon cancer.
|
16771692 |
2007 |
|
rs1052133
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population.
|
30429230 |
2019 |
|
rs1052133
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models.
|
24435978 |
2014 |
|
rs1052133
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.
|
24922697 |
2014 |
|
rs1052133
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis.
|
18628426 |
2008 |
|
rs1052133
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, the possible association of the hOGG1 Ser326Cys gene variant with insulin sensitivity was investigated in 279 normal glucose-tolerant subjects without history of cancer.
|
16333523 |
2006 |