rs1267969615
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by follow-up studies.
|
11181802 |
2001 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In studies conducted in several different populations, the M235T substitution in the angiotensinogen (AGT) locus has been associated with hypertension.
|
9034402 |
1997 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here.
|
15642127 |
2005 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined.
|
17190732 |
2007 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
rs1267969615
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI.
|
9034401 |
1997 |
rs1267969615
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One DNA polymorphism within exon 2- with threonine instead of methionine at position 235 (M235T) was found to be significantly associated with hypertension.
|
12169209 |
2003 |
rs1267969615
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggested that ACE I/D polymorphism, but not AGN M235T polymorphism, is a possible genetic risk factor for diabetic nephropathy in Japanese NIDDM patients.
|
8596493 |
1996 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism of the angiotensinogen gene may be associated with a higher risk of hypertension.
|
11134677 |
2000 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE (I/D) polymorphism showed no association with CHD, whereas the frequency distribution of AGT (M235T) genotypes among patients and controls (235T: 29.1% and 19.0%; M235T: 48.5% and 50.2%; M235: 22.4% and 30.8%, respectively) was statistically different (p = 0.005) and not related to the presence of essential hypertension.
|
11345362 |
2001 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
|
24860821 |
2014 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The formerly described, but controversial, association of the M235T polymorphism with arterial hypertension could not be confirmed in this study.
|
9950302 |
1999 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore investigated the association between ACE I/D, AGT M235T, and AT1 A1266C gene polymorphisms and early signs of target organ damage in 215 untreated patients with essential hypertension (EH).
|
10652033 |
2000 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension.
|
16685579 |
2006 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension.
|
9170002 |
1997 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension.
|
16981142 |
2006 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
rs1267969615
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
|
22974788 |
2012 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |
rs1267969615
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers.
|
14502296 |
2003 |
rs1267969615
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |