Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297

2014

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297

2014

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus. 22075267

2012

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. 18752089

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes. 19140096

2009

dbSNP: rs1800795
rs1800795
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250

2009

dbSNP: rs1800795
rs1800795
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. 17003362

2006

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE Our findings indicated that IL-6 rs1800795 polymorphism was significantly associated with individual susceptibility to IS in Asians, but not in Caucasians. 31446341

2019

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE We genotyped rs1800795 in overweight/obese women (<i>N</i> = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality. 28555011

2017

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE These findings suggest that GG SNP at IL-6: rs1800795 may indicate an increased risk of metastasis of primary breast cancer. 28732081

2017

dbSNP: rs1800795
rs1800795
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.060 GeneticVariation BEFREE We genotyped rs1800795 in overweight/obese women (<i>N</i> = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality. 28555011

2017

dbSNP: rs1800795
rs1800795
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.060 GeneticVariation BEFREE These findings suggest that GG SNP at IL-6: rs1800795 may indicate an increased risk of metastasis of primary breast cancer. 28732081

2017

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (-174 G>C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects. 27049557

2016

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE RESULTS The present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91-1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91-1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78-1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model). 27840402

2016

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNFα)-238 GA, interleukin( IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population. 26722564

2015

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE Mutant allele and genotype at IL-1β [+3954 C>T (rs1143634)] site associated with increased BC risk, while mutant allele and genotypes at IL-6 [-174 G>C (rs1800795)] polymorphism appeared to be protective. 22818022

2012

dbSNP: rs1800795
rs1800795
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.060 GeneticVariation BEFREE Mutant allele and genotype at IL-1β [+3954 C>T (rs1143634)] site associated with increased BC risk, while mutant allele and genotypes at IL-6 [-174 G>C (rs1800795)] polymorphism appeared to be protective. 22818022

2012

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous. 21536090

2011

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE The association between a single-nucleotide polymorphism (SNP) -174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous. 20043205

2010

dbSNP: rs1800795
rs1800795
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.060 GeneticVariation BEFREE The association between a single-nucleotide polymorphism (SNP) -174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous. 20043205

2010

dbSNP: rs1800795
rs1800795
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.060 GeneticVariation BEFREE We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke. 20622166

2010

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE Among women without recent hormone exposure, those with a WHR >0.9 and the rs1800795 GG genotype had a greater than threefold increased risk of breast cancer (odds ratios (ORs) 3.22, 95% confidence intervals (CIs) 1.27, 817) when compared with women with a WHR <0.8 and the rs1800795 GG genotype (P interaction 0.01). 18239642

2008

dbSNP: rs1800795
rs1800795
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.060 GeneticVariation BEFREE Among women without recent hormone exposure, those with a WHR >0.9 and the rs1800795 GG genotype had a greater than threefold increased risk of breast cancer (odds ratios (ORs) 3.22, 95% confidence intervals (CIs) 1.27, 817) when compared with women with a WHR <0.8 and the rs1800795 GG genotype (P interaction 0.01). 18239642

2008

dbSNP: rs1800795
rs1800795
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively). 17416766

2007