Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs747126003
rs747126003
CUI: C0028754
Disease: Obesity
Obesity
0.020 GeneticVariation BEFREE Polymorphisms in the adipokine genes, LEP, LEPR, and RETN were not associated with obesity susceptibility, whereas ADIPOQ G276T (T vs. G: odds ratio (OR), 1.59; 95% confidence interval (CI), 1.39-1.81), IL-1β C3953T (CC vs. CT+TT: OR, 1.61; 95% CI, 1.18-2.20), and TNF-α G308A (GG vs. GA+AA: OR, 1.19; 95% CI, 1.02-1.39) polymorphisms were associated with an increased risk of obesity. 21660081

2012

dbSNP: rs747126003
rs747126003
CUI: C0028754
Disease: Obesity
Obesity
0.020 GeneticVariation BEFREE We found a relation between G174C polymorphism in IL-6 gene and G308A in TNF-alpha gene with the occurrence of obesity. 20156727

2009

dbSNP: rs2069837
rs2069837
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.020 GeneticVariation BEFREE We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression. 23180271

2013

dbSNP: rs2069837
rs2069837
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.020 GeneticVariation BEFREE We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression. 23180271

2013

dbSNP: rs2069837
rs2069837
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.020 GeneticVariation BEFREE Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk. 27535759

2016

dbSNP: rs2069837
rs2069837
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.020 GeneticVariation BEFREE Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk. 27535759

2016

dbSNP: rs2069837
rs2069837
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.020 GeneticVariation BEFREE We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression. 23180271

2013

dbSNP: rs2069837
rs2069837
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.020 GeneticVariation BEFREE Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk. 27535759

2016

dbSNP: rs777906302
rs777906302
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.010 GeneticVariation BEFREE Our results suggest a possible association between the T300A variant and CD in this cohort of Algerian CD patients. 29519712

2018

dbSNP: rs777906302
rs777906302
CUI: C0262655
Disease: Recurrent urinary tract infection
Recurrent urinary tract infection
0.010 GeneticVariation BEFREE Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type. 30335568

2019

dbSNP: rs777906302
rs777906302
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection
0.010 GeneticVariation BEFREE Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type. 30335568

2019

dbSNP: rs747126003
rs747126003
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
0.010 GeneticVariation BEFREE The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. 28746216

2017

dbSNP: rs747126003
rs747126003
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.010 GeneticVariation BEFREE TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. 22160576

2012

dbSNP: rs747126003
rs747126003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.010 GeneticVariation BEFREE Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis. 30633155

2019

dbSNP: rs747126003
rs747126003
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. 22160576

2012

dbSNP: rs747126003
rs747126003
CUI: C3496337
Disease: Idiopathic Nephrotic Syndrome
Idiopathic Nephrotic Syndrome
0.010 GeneticVariation BEFREE IL-6-G174C and TNFα-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients. 29190601

2017

dbSNP: rs747126003
rs747126003
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.010 GeneticVariation BEFREE Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. 29228633

2017

dbSNP: rs747126003
rs747126003
CUI: C1704321
Disease: Nephrotic Syndrome, Minimal Change
Nephrotic Syndrome, Minimal Change
0.010 GeneticVariation BEFREE IL-6-G174C and TNFα-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients. 29190601

2017

dbSNP: rs747126003
rs747126003
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.010 GeneticVariation BEFREE Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. 29228633

2017

dbSNP: rs747126003
rs747126003
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.010 GeneticVariation BEFREE Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. 29228633

2017

dbSNP: rs747126003
rs747126003
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.010 GeneticVariation BEFREE TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children. 16444434

2006

dbSNP: rs747126003
rs747126003
CUI: C3826128
Disease: Infection in children
Infection in children
0.010 GeneticVariation BEFREE The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. 28746216

2017

dbSNP: rs747126003
rs747126003
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 GeneticVariation BEFREE In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied. 16444434

2006

dbSNP: rs747126003
rs747126003
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.010 GeneticVariation BEFREE The G308A polymorphism of the TNF-alpha gene did not affect levels of inflammatory markers in patients after surgery for head and neck cancer who were treated with early enteral nutrition. 17560079

2007

dbSNP: rs747126003
rs747126003
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm
0.010 GeneticVariation BEFREE The G308A polymorphism of the TNF-alpha gene did not affect levels of inflammatory markers in patients after surgery for head and neck cancer who were treated with early enteral nutrition. 17560079

2007