rs747126003
|
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphisms in the adipokine genes, LEP, LEPR, and RETN were not associated with obesity susceptibility, whereas ADIPOQ G276T (T vs. G: odds ratio (OR), 1.59; 95% confidence interval (CI), 1.39-1.81), IL-1β C3953T (CC vs. CT+TT: OR, 1.61; 95% CI, 1.18-2.20), and TNF-α G308A (GG vs. GA+AA: OR, 1.19; 95% CI, 1.02-1.39) polymorphisms were associated with an increased risk of obesity.
|
21660081 |
2012 |
rs747126003
|
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a relation between G174C polymorphism in IL-6 gene and G308A in TNF-alpha gene with the occurrence of obesity.
|
20156727 |
2009 |
rs2069837
|
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
rs2069837
|
|
Malignant tumor of cervix
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|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
rs2069837
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
rs2069837
|
|
Malignant tumor of cervix
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
rs2069837
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression.
|
23180271 |
2013 |
rs2069837
|
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.
|
27535759 |
2016 |
rs777906302
|
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest a possible association between the T300A variant and CD in this cohort of Algerian CD patients.
|
29519712 |
2018 |
rs777906302
|
|
Recurrent urinary tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type.
|
30335568 |
2019 |
rs777906302
|
|
Urinary tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Abbreviations: 3-PEHPC: 3-pyridinyl ethylidene hydroxyl phosphonocarboxylate; ATG: autophagy; ATG16L1: autophagy related 16 like 1; BECs: bladder epithelial cells; dpi: days post infection; hpi: hours post infection; IF: immunofluorescence; IL1B: interleukin 1 beta; IL6: interleukin 6; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MVB: multivesicular bodies; T300A: Thr300Ala; TNF: tumor necrosis factor; QIR(s): quiescent intracellular reservoir(s); siRNA: short interfering RNA; UPEC: uropathogenic Escherichia coli; UTI(s): urinary tract infection(s); TEM: transmission electron microscopy; WT: wild type.
|
30335568 |
2019 |
rs747126003
|
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania.
|
28746216 |
2017 |
rs747126003
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC.
|
22160576 |
2012 |
rs747126003
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis.
|
30633155 |
2019 |
rs747126003
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC.
|
22160576 |
2012 |
rs747126003
|
|
Idiopathic Nephrotic Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6-G174C and TNFα-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients.
|
29190601 |
2017 |
rs747126003
|
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
rs747126003
|
|
Nephrotic Syndrome, Minimal Change
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6-G174C and TNFα-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients.
|
29190601 |
2017 |
rs747126003
|
|
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
rs747126003
|
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
rs747126003
|
|
Severe Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children.
|
16444434 |
2006 |
rs747126003
|
|
Infection in children
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania.
|
28746216 |
2017 |
rs747126003
|
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied.
|
16444434 |
2006 |
rs747126003
|
|
Head and Neck Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G308A polymorphism of the TNF-alpha gene did not affect levels of inflammatory markers in patients after surgery for head and neck cancer who were treated with early enteral nutrition.
|
17560079 |
2007 |
rs747126003
|
|
Malignant Head and Neck Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G308A polymorphism of the TNF-alpha gene did not affect levels of inflammatory markers in patients after surgery for head and neck cancer who were treated with early enteral nutrition.
|
17560079 |
2007 |