|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, there was no statistically significant association between the risk of breast cancer and the MTHFR C677T genotype.
|
15736423 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Low dietary folate intake (P < 0.001), RFC1 G80A (OR: 1.38, 95% CI 1.06-1.81) and MTHFR C677T (OR: 1.74 (1.11-2.73) were independently associated with the breast cancer risk whereas cSHMT C1420T conferred protection (OR: 0.72, 95% CI 0.55-0.94).
|
21161404 |
2011 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, females carrying MTHFR C</span>677T CT or TT genotypes had a higher odds ratio of 1.21 (95% confidence interval=1.03-1.42, p=1.85E-5) for breast cancer, especially before the age of 45.4 years (odds ratio=1.51 and 95% confidence interval=1.20-1.90).
|
25075036 |
2014 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seventeen studies were included in the meta-analysis of MTHFR C677T genotype and breast cancer risk.
|
17105984 |
2006 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial.
|
25318348 |
2015 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, during this meta-analysis, we found that MTHFR C677T polymorphism was significantly associated with breast cancer risk in the Chinese population.
|
24078451 |
2014 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
After adjusting for age of menarche, parity, alcohol intake and total fat intake we observed reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles of serum folate concentrations of 0.23 (95% confidence interval (CI) 0.09, 0.54) for the entire group, 0.27 (CI 0.09, 0.80) for the wild-type and 0.08 (CI 0.01, 0.52) for the heterozygous C677T genotype.
|
15110890 |
2004 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study.
|
22901194 |
2012 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
It can be concluded that potentially functional MTHFR C677T polymorphism may play a low penetrance role in the development of breast cancer.
|
20135343 |
2010 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure.
|
17896178 |
2008 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of MTR A2756G mutant allele and MTHFR C677T mutant allele in carriers was associated with increased breast cancer risk [odds ration, 3.2 (P=0.16; 95% confidence interval, 0.76-13.9) and 3.9 (P=0.09; 95% confidence interval, 0.93-16.3), respectively].
|
18842997 |
2008 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T genotype may be associated with BC chemotherapy response, and could be of great value in guiding individualized treatment for this disease.
|
27706773 |
2016 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A reduced activity of methylenetetrahydrofolate reductase (MTHFR) due to frequent C677T polymorphism affects DNA synthesis, repair and methylation and may be implicated in breast cancer risk.
|
17260091 |
2007 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, among postmenopausal women, there was an increase in breast cancer risk for women who were homozygote TT for MTHFR C677T and had high lifetime alcohol intake (>or=1,161.84 oz; OR, 1.92; 95% CI, 1.13-3.28) and for those who had a high number of drinks per drinking day (>1.91 drinks/day; OR, 1.80; 95% CI, 1.03-3.28) compared with nondrinkers who were homozygote CC.
|
19706843 |
2009 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
|
12473175 |
2002 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283 healthy women.
|
21875371 |
2012 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the 677TT genotype of the C677T polymorphism in the MTHFR gene is associated with BC susceptibility in the Mexican population.
|
25966173 |
2015 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk.
|
15735051 |
2005 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association of TSER, MTHFR C677T, p53 codon 72 and MDR1 C3435T gene polymorphisms with breast carcinoma in women from Canary Islands (Spain).
|
19885596 |
2009 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis strongly suggested a significant association between the MTHFR C677T polymorphism and risk of breast cancer in Asian populations.
|
25081713 |
2014 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, individuals with the TT genotype of MTHFR 677C/T were associated with increased risk of breast cancer by logistic regression analysis; the adjusted odds ratio (95%CI) was 3.05 (1.17-8.87).
|
26662439 |
2015 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Encouraged by recent studies on the MTHFR 677C>T polymorphism and breast cancer risk that suggested an association of the 677 TT genotype with increased breast cancer susceptibility in premenopausal women, we performed an analysis of the relationship between breast cancer risk and the MTHFR 677C>T polymorphism in 210 premenopausal breast cancer patients and sex- and agematched healthy control subjects.
|
17453338 |
2008 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between methylenetetrahydrofolate reductase 677C>T polymorphisms and breast cancer susceptibility: A meta-analysis based on Chinese Han population.
|
26323926 |
2015 |