|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study confirms the association of Val66Met to substance-related disorders, eating disorders, and schizophrenia.
|
17217930 |
2007 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the association between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese patients with schizophrenia and 569 controls.
|
16854566 |
2006 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our population-based study and meta-analysis demonstrate that the BDNF C-270T and Val66Met polymorphisms do not play major roles in the susceptibility to schizophrenia in either Caucasian or Asian populations.
|
17289348 |
2007 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.
|
29595641 |
2018 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507).
|
24468644 |
2014 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.
|
18325670 |
2008 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia.
|
27262112 |
2017 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To characterize the neurocognitive and brain morphometric phenotypic correlates of the BDNF Val66Met polymorphism and to test the specificity of the BDNF(Met) variant on cognitive dysfunction in schizophrenia.
|
16818862 |
2006 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain derived neurotrophic factor (BDNF) val66met polymorphism rs6265 influences learning and may represent a risk factor for schizophrenia.
|
25125238 |
2014 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner.
|
21917241 |
2011 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia.
|
22477643 |
2012 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations.
|
30312750 |
2018 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
|
19018714 |
2008 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease.
|
20420877 |
2010 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia.
|
18056245 |
2007 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data provide evidence that the BDNF Val66Met polymorphism may be involved in the etiology of schizophrenia in a Chinese Han population.
|
23532065 |
2013 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The overall analysis for investigating the association of the G196A allele G and the risk of developing schizophrenia relative to the allele A, showed significant evidence of heterogeneity (P=0.05, I(2)=58%) between the studies and nonsignificant association [random effects odds ratio 1.08 and 95% confidence interval (0.88-1.32)].
|
17413445 |
2007 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated.
|
21305693 |
2011 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053).
|
19406621 |
2009 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.
|
23319002 |
2013 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study tested, in a sample of 94 nuclear families, the hypothesis that the BDNF gene Val66Met polymorphism is associated to SZ and its psychopathologic phenotype using a multidimensional symptom approach.
|
16389585 |
2006 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is evidence that val66met polymorphism may be involved in the pathophysiology of schizophrenia.
|
23487199 |
2013 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder.
|
15543516 |
2004 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant differences in genotype or allele distribution of Val66Met were identified between aggressive and non-aggressive schizophrenia patients.
|
24289908 |
2014 |
|
rs759834365
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the Val66Met polymorphism was not associated with aggressiveness in patients with schizophrenia.
|
20579509 |
2010 |